(E)-ethyl 2-(5-fluoro-1-((5-(p-tolyl)isoxazol-3-yl)methylene)-1H-inden-3-yl)-2-methylpropanoate

Base Information

Chemical Name:(E)-ethyl 2-(5-fluoro-1-((5-(p-tolyl)isoxazol-3-yl)methylene)-1H-inden-3-yl)-2-methylpropanoate
CAS No.:1361001-13-9
Molecular Formula:C₂₆H₂₄FNO₃
Molecular Weight:417.48
Hs Code.:

Synonyms:(E)-ethyl 2-(5-fluoro-1-((5-(p-tolyl)isoxazol-3-yl)methylene)-1H-inden-3-yl)-2-methylpropanoate

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Chemical Property of (E)-ethyl 2-(5-fluoro-1-((5-(p-tolyl)isoxazol-3-yl)methylene)-1H-inden-3-yl)-2-methylpropanoate

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Technology Process of (E)-ethyl 2-(5-fluoro-1-((5-(p-tolyl)isoxazol-3-yl)methylene)-1H-inden-3-yl)-2-methylpropanoate

There total 4 articles about (E)-ethyl 2-(5-fluoro-1-((5-(p-tolyl)isoxazol-3-yl)methylene)-1H-inden-3-yl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1361000-79-4
ethyl 2-(5-fluoro-1H-inden-3-yl)-2-methylpropanoate

: 640292-02-0
5-(4-methylphenyl)-1,2-oxazole-3-carbaldehyde

: 1361001-13-9
(E)-ethyl 2-(5-fluoro-1-((5-(p-tolyl)isoxazol-3-yl)methylene)-1H-inden-3-yl)-2-methylpropanoate

Guidance literature:: With sodium hydroxide; In methanol; at 20 - 70 ℃;
DOI:10.1021/jm201528b

Reference yield:

: 1361000-76-1
ethyl 2-(6-fluoro-1-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-methylpropanoate

: 1361001-13-9
(E)-ethyl 2-(5-fluoro-1-((5-(p-tolyl)isoxazol-3-yl)methylene)-1H-inden-3-yl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; calcium chloride / toluene / 16 h / Reflux

2: sodium hydroxide / methanol / 20 - 70 °C

With toluene-4-sulfonic acid; calcium chloride; sodium hydroxide; In methanol; toluene;
DOI:10.1021/jm201528b

Reference yield:

: 97-62-1
Ethyl isobutyrate

: 1361001-13-9
(E)-ethyl 2-(5-fluoro-1-((5-(p-tolyl)isoxazol-3-yl)methylene)-1H-inden-3-yl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -75 °C / Inert atmosphere

1.2: 2 h / -75 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid; calcium chloride / toluene / 16 h / Reflux

3.1: sodium hydroxide / methanol / 20 - 70 °C

With toluene-4-sulfonic acid; calcium chloride; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; toluene;
DOI:10.1021/jm201528b