N-[2-(1-methoxybut-3-ynyl)phenyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[2-(1-methoxybut-3-ynyl)phenyl]-4-methylbenzenesulfonamide
• CAS No.: 1379771-10-4
• Molecular Formula: C₁₈H₁₉NO₃S
• Molecular Weight: 329.42
• Mol file: 1379771-10-4.mol

Synonyms:N-[2-(1-methoxybut-3-ynyl)phenyl]-4-methylbenzenesulfonamide

Chemical Property of N-[2-(1-methoxybut-3-ynyl)phenyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(1-methoxybut-3-ynyl)phenyl]-4-methylbenzenesulfonamide

There total 4 articles about N-[2-(1-methoxybut-3-ynyl)phenyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(1-methoxybut-3-ynyl)aniline (1379771-08-0) + p-toluenesulfonyl chloride (98-59-9) → N-[2-(1-methoxybut-3-ynyl)phenyl]-4-methylbenzenesulfonamide (1379771-10-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo300458v

Reference yield:

1-(2-nitrophenyl)but-3-yn-1-ol (127559-58-4) → N-[2-(1-methoxybut-3-ynyl)phenyl]-4-methylbenzenesulfonamide (1379771-10-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: iron; acetic acid / ethanol; water / 2 h / Reflux; Inert atmosphere

3.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; iron; sodium hydride; acetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo300458v

Reference yield:

C11H11NO3 (1379771-06-8) → N-[2-(1-methoxybut-3-ynyl)phenyl]-4-methylbenzenesulfonamide (1379771-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; acetic acid / ethanol; water / 2 h / Reflux; Inert atmosphere

2: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; iron; acetic acid; In ethanol; dichloromethane; water;

DOI:10.1021/jo300458v

upstream raw materials:

C₁₁H₁₁NO₃

2-(1-methoxybut-3-ynyl)aniline

p-toluenesulfonyl chloride

1-(2-nitrophenyl)but-3-yn-1-ol

Downstream raw materials:

C₂₄H₂₃NO₃S

N-[2-(1-methoxybut-3-ynyl)phenyl]-4-methylbenzenesulfonamide

(E)-2-(4-methylbenzylidene)-4-methoxy-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

1,4-bis[(E)-4-methoxy-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline-2-methylideno]benzene