(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid

Base Information

Chemical Name:(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid
CAS No.:213383-02-9
Molecular Formula:C28H29NO4
Molecular Weight:443.53
Hs Code.:2922498590
European Community (EC) Number:830-710-3
DSSTox Substance ID:DTXSID10375796
Wikidata:Q72478915
Mol file:213383-02-9.mol

Synonyms:213383-02-9;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid;Fmoc-4-tert-butyl-L-phenylalanine;FMOC-L-4-TERT-BUTYL-PHE;(2S)-3-(4-tert-butylphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid;FMOC-P-TBU-PHE-OH;FMOC-L-4-TETR-BUTYLPHENYLALANINE;FMOC-L-PHE(4-TBU)-OH;FMOC-PHE(4-TBU)-OH;SCHEMBL3725046;DTXSID10375796;2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid;MFCD02094466;AKOS015948701;FMOC-4-T-BUTYL-L-PHENYLALANINE;FMOC-L-4-TERT-BUTYLPHENYLALANINE;AC-25347;PS-12160;CS-0101060;4-tert-Butyl-L-phenylalanine, N-FMOC protected;EN300-1273029;A879150;J-505177;Fmoc-L-4-tert-butyl-phenylalanine (Fmoc-L-Phe(4-tBu)-OH);(S)-FMOC-2-AMINO-3-(4-TERT-BUTYL-PHENYL)PROPIONIC ACID;(2S)-3-(4-tert-butylphenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoicacid;(s)-2-(((9h-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butylphenyl)propanoic acid;4-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine

Suppliers and Price of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Fmoc-4-tert-butyl-L-phenylalanine
500mg
$ 333.00

Usbiological
Fmoc-L-4-tert-butyl-Phe
100mg
$ 305.00

TRC
Fmoc-L-4-tert-butyl-Phe
100mg
$ 45.00

Crysdot
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoicacid 95+%
5g
$ 325.00

Crysdot
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoicacid 95+%
10g
$ 618.00

Crysdot
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoicacid 95+%
25g
$ 1325.00

chempep
Fmoc-Phe(4-tBu)-OH
100g
$ 2000.00

chempep
Fmoc-Phe(4-tBu)-OH
25g
$ 800.00

chempep
Fmoc-Phe(4-tBu)-OH
5g
$ 200.00

Chem-Impex
Fmoc-4--butyl-L-phenylalanine ≥ 98% (HPLC)
1G
$ 55.00

Total 32 raw suppliers

Chemical Property of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid

Chemical Property:

Vapor Pressure:3.82E-17mmHg at 25°C
Refractive Index:1.6
Boiling Point:637.9 °C at 760 mmHg
PKA:3.81±0.10(Predicted)
Flash Point:339.6 °C
PSA：75.63000
Density:1.198 g/cm³
LogP:5.90940
Storage Temp.:2-8°C
XLogP3:6.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:443.20965841
Heavy Atom Count:33
Complexity:656

Purity/Quality:

99%, ^*data from raw suppliers

Fmoc-4-tert-butyl-L-phenylalanine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C1=CC=C(C=C1)CC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
Isomeric SMILES:CC(C)(C)C1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid

There total 5 articles about (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 82372-74-5,274262-82-7
(2S)-2-amino-3-(4-tert-butylphenyl)propanoic acid

: 213383-02-9
4-tert-butyl-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-phenylalanine

Guidance literature:: With sodium carbonate; In 1,4-dioxane; 1.) 0-5 deg C, 2 h, 2.) -> room temperature, 1.5 h;
DOI:10.1080/00397919808004880

Reference yield:

: 18880-00-7
1-(bromomethyl)-4-(1,1-dimethylethyl)benzene

: 213383-02-9
4-tert-butyl-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-phenylalanine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaOEt / 1.) EtOH, reflux, 1 h, 2.) EtOH, 0-5 deg C, 4 h

2: aq. NaOH / 21 h / Heating

3: conc. HCl / Heating

4: 92 percent / aq. LiOH / 48 h / 40 °C / porcine kidney acylase

5: 53 percent / aq. Na₂CO₃ / dioxane / 1.) 0-5 deg C, 2 h, 2.) -> room temperature, 1.5 h

With hydrogenchloride; lithium hydroxide; sodium hydroxide; sodium ethanolate; sodium carbonate; In 1,4-dioxane;
DOI:10.1080/00397919808004880

Reference yield:

: 2-Acetylamino-2-(4-tert-butyl-benzyl)-malonic acid

: 213383-02-9
4-tert-butyl-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: conc. HCl / Heating

2: 92 percent / aq. LiOH / 48 h / 40 °C / porcine kidney acylase

3: 53 percent / aq. Na₂CO₃ / dioxane / 1.) 0-5 deg C, 2 h, 2.) -> room temperature, 1.5 h

With hydrogenchloride; lithium hydroxide; sodium carbonate; In 1,4-dioxane;
DOI:10.1080/00397919808004880