(R)-tert-butyl 3-(4-(3-(4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl)propanoate

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Chemical Name:(R)-tert-butyl 3-(4-(3-(4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl)propanoate
CAS No.:1311258-45-3
Molecular Formula:C₂₈H₂₈F₃N₃O₅
Molecular Weight:543.543
Hs Code.:

Synonyms:(R)-tert-butyl 3-(4-(3-(4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl)propanoate

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Chemical Property of (R)-tert-butyl 3-(4-(3-(4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl)propanoate

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Technology Process of (R)-tert-butyl 3-(4-(3-(4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl)propanoate

There total 5 articles about (R)-tert-butyl 3-(4-(3-(4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1311258-44-2
(R)-5-(1H-indol-4-yl)-3-(4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

: 1311258-45-3
(R)-tert-butyl 3-(4-(3-(4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl)propanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 50 ℃; for 18h;

Reference yield:

: 124811-71-8
4-hydroxy-3-(trifluoromethyl)benzonitrile

: 1311258-45-3
(R)-tert-butyl 3-(4-(3-(4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: hydroxylamine / ethanol; water / 18 h / 60 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 2 h / 140 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 18 h / 50 °C

With di-isopropyl azodicarboxylate; hydroxylamine; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1311255-47-6
(R)-4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)benzonitrile

: 1311258-45-3
(R)-tert-butyl 3-(4-(3-(4-(tetrahydrofuran-3-yloxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)-1H-indol-1-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine / ethanol; water / 18 h / 60 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 140 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 18 h / 50 °C

With hydroxylamine; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;