(R)-3-{4-[2-(2-phenyl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

Base Information

Chemical Name:(R)-3-{4-[2-(2-phenyl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester
CAS No.:401790-93-0
Molecular Formula:C₃₀H₃₁NO₅
Molecular Weight:485.58
Hs Code.:

Synonyms:(R)-3-{4-[2-(2-phenyl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-{4-[2-(2-phenyl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

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Technology Process of (R)-3-{4-[2-(2-phenyl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

There total 12 articles about (R)-3-{4-[2-(2-phenyl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 170861-68-4
toluene-4-sulfonic acid 2-(5-methyl-2-phenyl-oxazol-4-yl)-ethyl ester

: 401468-51-7
(R)-(+)-3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionic acid ethyl ester

: 401790-93-0
(R)-3-{4-[2-(2-phenyl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 55 ℃;
DOI:10.1016/j.bmcl.2004.09.031

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 401790-93-0
(R)-3-{4-[2-(2-phenyl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / LDA / -78 °C

2: 100 percent / pyridine / CH₂Cl₂

3: 90 percent / H₂ / Pd/C / ethyl acetate

4: Chiralpak AD

5: 70 percent / Cs₂CO₃ / dimethylformamide / 55 °C

With pyridine; hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.09.031

Reference yield:

: 42412-84-0
ethyl 2-phenoxypropionate

: 401790-93-0
(R)-3-{4-[2-(2-phenyl-5-methyloxazol-4-yl)ethoxy]phenyl}-2-phenoxypropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / LDA / -78 °C

2: 100 percent / pyridine / CH₂Cl₂

3: 90 percent / H₂ / Pd/C / ethyl acetate

4: Chiralpak AD

5: 70 percent / Cs₂CO₃ / dimethylformamide / 55 °C

With pyridine; hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.09.031