7,8-dibenzyloxy-6-[3-{(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)hydroxymethyl}-4,5-dihydroisoxazol-5-yl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

Base Information

Chemical Name:7,8-dibenzyloxy-6-[3-{(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)hydroxymethyl}-4,5-dihydroisoxazol-5-yl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester
CAS No.:1315508-05-4
Molecular Formula:C₅₆H₄₉NO₁₃
Molecular Weight:944.004
Hs Code.:

7,8-dibenzyloxy-6-[3-{(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)hydroxymethyl}-4,5-dihydroisoxazol-5-yl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

Synonyms:7,8-dibenzyloxy-6-[3-{(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)hydroxymethyl}-4,5-dihydroisoxazol-5-yl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

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Chemical Property of 7,8-dibenzyloxy-6-[3-{(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)hydroxymethyl}-4,5-dihydroisoxazol-5-yl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7,8-dibenzyloxy-6-[3-{(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)hydroxymethyl}-4,5-dihydroisoxazol-5-yl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

There total 8 articles about 7,8-dibenzyloxy-6-[3-{(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)hydroxymethyl}-4,5-dihydroisoxazol-5-yl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1315508-04-3
7,8-dibenzyloxy-6-[3-{(tert-butyldimethylsilanyloxy)(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)-methyl}-4,5-dihydroisoxazol-5-yl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

: 1315508-05-4
7,8-dibenzyloxy-6-[3-{(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)hydroxymethyl}-4,5-dihydroisoxazol-5-yl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

Guidance literature:: With hydrogen fluoride; In acetonitrile; at 20 ℃; for 2.5h;
DOI:10.1021/jo200399z

Reference yield:

: 1012037-70-5
ethyl 3,4-dihydro-5,6,8-trimethoxy-3,4-dioxonaphthalene-2-carboxylate

: 1315508-05-4
7,8-dibenzyloxy-6-[3-{(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)hydroxymethyl}-4,5-dihydroisoxazol-5-yl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium dithionite; water / benzene / 0.08 h

2.1: potassium carbonate / 6 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

4.1: Dess-Martin periodane / dichloromethane / 1 h

5.1: n-butyllithium / tetrahydrofuran / 0.5 h / Cooling with ice

5.2: 26 h / 20 °C

6.1: dichloromethane / 40 h / 50 - 55 °C

7.1: 4-Nitrophenyl isocyanate; triethylamine / toluene / 15 h / 130 - 135 °C

8.1: hydrogen fluoride / acetonitrile / 2.5 h / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; sodium dithionite; hydrogen fluoride; water; 4-Nitrophenyl isocyanate; potassium carbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; dichloromethane; toluene; acetonitrile; benzene; 5.1: Henry reaction / 5.2: Henry reaction;
DOI:10.1021/jo200399z

Reference yield:

: C₁₆H₁₈O₇

: 1315508-05-4
7,8-dibenzyloxy-6-[3-{(3,4-dibenzyloxy-5,6,8-trimethoxynaphthalen-2-yl)hydroxymethyl}-4,5-dihydroisoxazol-5-yl]-1-oxo-1H-isochromene-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / 6 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

3.1: Dess-Martin periodane / dichloromethane / 1 h

4.1: n-butyllithium / tetrahydrofuran / 0.5 h / Cooling with ice

4.2: 26 h / 20 °C

5.1: dichloromethane / 40 h / 50 - 55 °C

6.1: 4-Nitrophenyl isocyanate; triethylamine / toluene / 15 h / 130 - 135 °C

7.1: hydrogen fluoride / acetonitrile / 2.5 h / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; hydrogen fluoride; 4-Nitrophenyl isocyanate; potassium carbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; dichloromethane; toluene; acetonitrile; 4.1: Henry reaction / 4.2: Henry reaction;
DOI:10.1021/jo200399z