(R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID

Base Information

• Chemical Name: (R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID
• CAS No.: 73025-69-1
• Molecular Formula: C₉H₁₁NO₃*ClH
• Molecular Weight: 217.652
• Hs Code.: 2922509090
• Mol file: 73025-69-1.mol

Synonyms:L-BETA-HOMO(4-HYDROXYPHENYL)GLYCINE;H-PHG(4-OH)-(C*CH2)OH;H-D-BETA-PHE(4-OH)-OH;(R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID;H-D-b-Phe(4-OH)-OH;S-4-NO2-PHA;Albb-007468;H-D-β-Phe(4-OH)-OH

Chemical Property of (R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 3.42E-07mmHg at 25°C
• Boiling Point: 402.3 °C at 760 mmHg
• Flash Point: 197.1 °C
• PSA: 83.55000
• LogP: 1.56700

Purity/Quality:

99.3% ^*data from raw suppliers

(R)-3-Amino-3-(4-hydroxyphenyl)propanoicacidhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-3-Amino-3-(4-hydroxy-phenyl)propionic Acid can be used to treat bacterial infections.

Technology Process of (R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID

There total 6 articles about (R)-3-AMINO-3-(4-HYDROXY-PHENYL)-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-benzyloxybenzaldehyde (4397-53-9) → (R)-β-tyrosine hydrochloride (73025-69-1)

Guidance literature:

Multi-step reaction with 6 steps

2: 89 percent / NaOH / methanol; H₂O / 7 h / Ambient temperature

3: DCC, DMAP / CH₂Cl₂ / 1.) 0 deg C, 2h, 2.) r.t., 16 h

4: 97 percent / NaOH / H₂O; methanol / 4 h / Heating

5: 98 percent / KHCO₃ / dimethylformamide / 12 h / Ambient temperature

With dmap; sodium hydroxide; potassium hydrogencarbonate; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)82374-6

Reference yield:

3-(4-Benzyloxy-phenyl)-3-tert-butoxycarbonylamino-propionic acid (618110-19-3) → (R)-β-tyrosine hydrochloride (73025-69-1)

Guidance literature:

Multi-step reaction with 4 steps

1: DCC, DMAP / CH₂Cl₂ / 1.) 0 deg C, 2h, 2.) r.t., 16 h

2: 97 percent / NaOH / H₂O; methanol / 4 h / Heating

3: 98 percent / KHCO₃ / dimethylformamide / 12 h / Ambient temperature

With dmap; sodium hydroxide; potassium hydrogencarbonate; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)82374-6

Reference yield:

(R)-3-(4-Benzyloxy-phenyl)-3-tert-butoxycarbonylamino-propionic acid → (R)-β-tyrosine hydrochloride (73025-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / KHCO₃ / dimethylformamide / 12 h / Ambient temperature

With potassium hydrogencarbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)82374-6

upstream raw materials:

(R)-3-(4-Benzyloxy-phenyl)-3-tert-butoxycarbonylamino-propionic acid methyl ester

p-benzyloxybenzaldehyde

3-(4-Benzyloxy-phenyl)-3-tert-butoxycarbonylamino-propionic acid

3-(4-Benzyloxy-phenyl)-3-tert-butoxycarbonylamino-propionic acid methyl ester