(3R,4S-cis)-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one

Base Information

Chemical Name:(3R,4S-cis)-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one
CAS No.:138383-37-6
Molecular Formula:C₂₁H₂₅ClN₂O₃
Molecular Weight:388.894
Hs Code.:

Synonyms:(3R,4S-cis)-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one

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Chemical Property of (3R,4S-cis)-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one

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Technology Process of (3R,4S-cis)-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one

There total 24 articles about (3R,4S-cis)-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5367-28-2
5-chloro-2-nitrotoluene

: 138337-22-1,138383-37-6
cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / dimethylformamide / Ambient temperature

2: SnCl₂*2H₂O, conc. HCl / methanol / 4.5 h

3: CH₃ONa / methanol / 3 h / Heating

4: 1.) potassium hexamethyldisilazide, 2.) trimethylphosphite, O₂ / 1.) THF, -78 deg C, 1 h, 2.) THF, 0 deg C, 30 min

5: LiI, H₂O / pyridine / 1.5 h / Heating

6: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, toluene, 80 deg C, 3 h

With hydrogenchloride; water; oxygen; sodium methylate; potassium hexamethylsilazane; sodium hydride; tin(ll) chloride; lithium iodide; phosphorous acid trimethyl ester; In pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00082a020

Reference yield:

: 107966-99-4
[2-(2-amino-5-chlorophenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid,dimethyl ester

: 138337-22-1,138383-37-6
cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: CH₃ONa / methanol / 3 h / Heating

2: 1.) potassium hexamethyldisilazide, 2.) trimethylphosphite, O₂ / 1.) THF, -78 deg C, 1 h, 2.) THF, 0 deg C, 30 min

3: LiI, H₂O / pyridine / 1.5 h / Heating

4: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, toluene, 80 deg C, 3 h

With water; oxygen; sodium methylate; potassium hexamethylsilazane; sodium hydride; lithium iodide; phosphorous acid trimethyl ester; In pyridine; methanol;
DOI:10.1021/jm00082a020

Reference yield:

: 107966-98-3
[2-(5-chloro-2-nitrophenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid,dimethyl ester

: 138337-22-1,138383-37-6
cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-7-chloro-2H-1-benzazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: SnCl₂*2H₂O, conc. HCl / methanol / 4.5 h

2: CH₃ONa / methanol / 3 h / Heating

3: 1.) potassium hexamethyldisilazide, 2.) trimethylphosphite, O₂ / 1.) THF, -78 deg C, 1 h, 2.) THF, 0 deg C, 30 min

4: LiI, H₂O / pyridine / 1.5 h / Heating

5: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, toluene, 80 deg C, 3 h

With hydrogenchloride; water; oxygen; sodium methylate; potassium hexamethylsilazane; sodium hydride; tin(ll) chloride; lithium iodide; phosphorous acid trimethyl ester; In pyridine; methanol;
DOI:10.1021/jm00082a020