BOC-D-4-TERT-BUTYL-PHE

Base Information

• Chemical Name: BOC-D-4-TERT-BUTYL-PHE
• CAS No.: 250611-12-2
• Molecular Formula: C₁₈H₂₇NO₄
• Molecular Weight: 321.417
• Hs Code.: 2924299090
• Mol file: 250611-12-2.mol

Synonyms:N-(tert-butoxycarbonyl)-4-tert-butyl-D-phenylalanine;(2R)-2-[(tert-butoxycarbonyl)amino]-3-(4-tert-butylphenyl)propanoic acid;4-tert-Butyl-L-phenylalanine, N-BOC protected;Boc-4-tert-butyl-D-phenylalanine;Boc-4-tert-butyl-D-Phe-OH;Boc-D-4-tert-butyl-Phe;

Chemical Property of BOC-D-4-TERT-BUTYL-PHE

Chemical Property:

• Boiling Point: 461.413 °C at 760 mmHg
• Flash Point: 232.855 °C
• PSA: 75.63000
• Density: 1.088 g/cm³
• LogP: 3.89540
• Storage Temp.: -15°C

Purity/Quality:

98%min ^*data from raw suppliers

(R)-2-((tert-Butoxycarbonyl)amino)-3-(4-(tert-butyl)phenyl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-D-4-TERT-BUTYL-PHE

There total 2 articles about BOC-D-4-TERT-BUTYL-PHE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (2S)-2-amino-3-(4-tert-butylphenyl)propanoic acid (82372-74-5,274262-82-7) → (2S)-2-[[(tert-butoxy)carbonyl]amino]-3-(4-tert-butylphenyl)propanoic acid (143415-62-7,250611-12-2)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water; at 0 - 20 ℃; for 3h;

Reference yield:

→ (2S)-2-[[(tert-butoxy)carbonyl]amino]-3-(4-tert-butylphenyl)propanoic acid (143415-62-7,250611-12-2)

Guidance literature:

Reference yield:

(2S)-2-[[(tert-butoxy)carbonyl]amino]-3-(4-tert-butylphenyl)propanoic acid (143415-62-7,250611-12-2) + (2S,4S)-4-fluoropyrrolidine-2-carbonitrile; 4-methylbenzene-1-sulfonic acid (483366-11-6) → tert-butyl N-[(2S)-1-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-3-(4-tert-butylphenyl)-1-oxopropan-2-yl]carbamate

Guidance literature:

(2S)-2-[[(tert-butoxy)carbonyl]amino]-3-(4-tert-butylphenyl)propanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.5h;

(2S,4S)-4-fluoropyrrolidine-2-carbonitrile; 4-methylbenzene-1-sulfonic acid; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

DOI:10.1016/j.bmc.2013.09.048

upstream raw materials:

di-tert-butyl dicarbonate

(2S)-2-amino-3-(4-tert-butylphenyl)propanoic acid

Downstream raw materials:

(3S)-7-tert-Butyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid

2-[(tert-butyl)oxycarbonyl]-7-(tert-butyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Refernces

• 1、 -. "ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS". Page/Page column 225; 226. . Retrieved 2016/12/07.