AC-YVAD-CMK

Base Information

• Chemical Name: AC-YVAD-CMK
• CAS No.: 178603-78-6
• Molecular Formula: C24H33 Cl N4 O8
• Molecular Weight: 540.99
• Mol file: 178603-78-6.mol

Synonyms:L-Alaninamide,N-acetyl-L-tyrosyl-L-valyl-N-[1-(carboxymethyl)-3-chloro-2-oxopropyl]-, (S)-;22: PN: WO2005039629 PAGE: 18 claimed protein; 2: PN: FR2926995 PAGE: 6 claimedprotein; 6: PN: WO0158526 SEQID: 6 claimed protein

Chemical Property of AC-YVAD-CMK

Chemical Property:

• PSA: 191.00000
• LogP: 1.41590
• Storage Temp.: −20°C
• Solubility.: DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Caspase-1 Inhibitor II ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical] Ac-YVAD-cmk has been used:as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulationas a caspase-1 inhibitor injected to C57BL/6 miceas a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injuryto abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth?in vivo?condition