(R)-N-(2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl))-2-fluorophenyl piperazin-1-yl)-2-oxoethyl)acetamide

Base Information

Chemical Name:(R)-N-(2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl))-2-fluorophenyl piperazin-1-yl)-2-oxoethyl)acetamide
CAS No.:1448996-61-9
Molecular Formula:C₂₀H₂₄FN₇O₄
Molecular Weight:445.453
Hs Code.:

Synonyms:(R)-N-(2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl))-2-fluorophenyl piperazin-1-yl)-2-oxoethyl)acetamide

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Chemical Property of (R)-N-(2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl))-2-fluorophenyl piperazin-1-yl)-2-oxoethyl)acetamide

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Technology Process of (R)-N-(2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl))-2-fluorophenyl piperazin-1-yl)-2-oxoethyl)acetamide

There total 5 articles about (R)-N-(2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl))-2-fluorophenyl piperazin-1-yl)-2-oxoethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1448996-60-8
(R)-2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl) piperazin-1-yl)-2-oxoethanaminium 2,2,2-trifluoroacetate

: 108-24-7
acetic anhydride

: 1448996-61-9
(R)-N-(2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl))-2-fluorophenyl piperazin-1-yl)-2-oxoethyl)acetamide

Guidance literature:: With triethylamine; In dichloromethane; acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2013.05.041

Reference yield:

: 1448996-58-4
C₂₃H₃₀FN₇O₅

: 1448996-61-9
(R)-N-(2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl))-2-fluorophenyl piperazin-1-yl)-2-oxoethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C

2: triethylamine / acetonitrile; dichloromethane / 0 - 20 °C

With triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.041

Reference yield:

: 154590-64-4
(S)-N-[3-[3-fluoro-4-[N-t-butoxycarbonylpiperazin-1-yl]phenyl]-2-oxooxazolidin-5-ylmethyl]azide

: 1448996-61-9
(R)-N-(2-(4-(4-(5-((1H-1,2,3-triazol-1-yl)methyl)-2-oxooxazolidin-3-yl))-2-fluorophenyl piperazin-1-yl)-2-oxoethyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,2-dimethoxyethane / 90 °C

2.1: dichloromethane / 0 - 20 °C

3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: dichloromethane / 0 - 20 °C

5.1: triethylamine / acetonitrile; dichloromethane / 0 - 20 °C

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2013.05.041