(R)-dimethyl <<4-<<(R)-phenylethoxy>carbonyl>-3-hydroxybutyryl>methyl>phosphonate

Base Information

Chemical Name:(R)-dimethyl <<4-<<(R)-phenylethoxy>carbonyl>-3-hydroxybutyryl>methyl>phosphonate
CAS No.:96555-53-2
Molecular Formula:C₁₆H₂₃O₇P
Molecular Weight:358.328
Hs Code.:

Synonyms:(R)-dimethyl <<4-<<(R)-phenylethoxy>carbonyl>-3-hydroxybutyryl>methyl>phosphonate

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Chemical Property of (R)-dimethyl <<4-<<(R)-phenylethoxy>carbonyl>-3-hydroxybutyryl>methyl>phosphonate

Chemical Property:

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Technology Process of (R)-dimethyl <<4-<<(R)-phenylethoxy>carbonyl>-3-hydroxybutyryl>methyl>phosphonate

There total 4 articles about (R)-dimethyl <<4-<<(R)-phenylethoxy>carbonyl>-3-hydroxybutyryl>methyl>phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 34939-91-8,58648-56-9
dimethyl lithiomethylphosphonate

: 96575-20-1
(3R,1'R)-methyl 1'-phenylethyl 3-hydroxypentanedioate

: 96555-53-2
(R)-dimethyl <<4-<<(R)-phenylethoxy>carbonyl>-3-hydroxybutyryl>methyl>phosphonate

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 0.166667h;
DOI:10.1021/ja00298a062

Reference yield:

: 96555-51-0
(3R,1'R)-methyl 1'-phenylethyl 3-<(tert-butyldimethylsilyl)oxy>pentanedioate

: 96555-53-2
(R)-dimethyl <<4-<<(R)-phenylethoxy>carbonyl>-3-hydroxybutyryl>methyl>phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / aq. HF / acetonitrile / 1.25 h / Ambient temperature

2: 1.) N-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, from -78 deg C to RT

With n-butyllithium; hydrogen fluoride; In acetonitrile;
DOI:10.1021/jm00393a030

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 96555-53-2
(R)-dimethyl <<4-<<(R)-phenylethoxy>carbonyl>-3-hydroxybutyryl>methyl>phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N / 1.) DMAP, -30 deg C

2: HF / acetonitrile

3: 43 percent / tetrahydrofuran / 0.17 h / -78 °C

With hydrogen fluoride; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ja00298a062