4-N-((1S,3R)-3-triisopropylsiloxy-1-(3,4-dimethoxyphenyl)-1-butyl)-aminophenol

Base Information

• Chemical Name: 4-N-((1S,3R)-3-triisopropylsiloxy-1-(3,4-dimethoxyphenyl)-1-butyl)-aminophenol
• CAS No.: 611185-13-8
• Molecular Formula: C₂₇H₄₃NO₄Si
• Molecular Weight: 473.728

Synonyms:4-N-((1S,3R)-3-triisopropylsiloxy-1-(3,4-dimethoxyphenyl)-1-butyl)-aminophenol

Chemical Property of 4-N-((1S,3R)-3-triisopropylsiloxy-1-(3,4-dimethoxyphenyl)-1-butyl)-aminophenol

Chemical Property:

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Technology Process of 4-N-((1S,3R)-3-triisopropylsiloxy-1-(3,4-dimethoxyphenyl)-1-butyl)-aminophenol

There total 3 articles about 4-N-((1S,3R)-3-triisopropylsiloxy-1-(3,4-dimethoxyphenyl)-1-butyl)-aminophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-((1S,3R)-3-triisopropylsiloxy-1-(3,4-dimethoxyphenyl)-1-butyl)-N-(4-tert-butyldimethylsiloxyphenyl)amine (611185-11-6) → 4-N-((1S,3R)-3-triisopropylsiloxy-1-(3,4-dimethoxyphenyl)-1-butyl)-aminophenol (611185-13-8)

Guidance literature:

With potassium carbonate; In methanol; at 40 ℃; for 4h;

DOI:10.1021/ja0372513

Reference yield:

TIPSOTf (130649-59-1) → 4-N-((1S,3R)-3-triisopropylsiloxy-1-(3,4-dimethoxyphenyl)-1-butyl)-aminophenol (611185-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / 2,6-lutidine / CH₂Cl₂ / 3 h / 20 °C

2: 90 percent / K₂CO₃ / methanol / 4 h / 40 °C

With 2,6-dimethylpyridine; potassium carbonate; In methanol; dichloromethane;

DOI:10.1021/ja0372513

Reference yield:

(4S)-4-(N-tert-butyldimethylsiloxyphenylamino)-4-(3,4-dimethoxyphenyl)-2-butanol → 4-N-((1S,3R)-3-triisopropylsiloxy-1-(3,4-dimethoxyphenyl)-1-butyl)-aminophenol (611185-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / 2,6-lutidine / CH₂Cl₂ / 3 h / 20 °C

2: 90 percent / K₂CO₃ / methanol / 4 h / 40 °C

With 2,6-dimethylpyridine; potassium carbonate; In methanol; dichloromethane;

DOI:10.1021/ja0372513

upstream raw materials:

N-((1S,3R)-3-triisopropylsiloxy-1-(3,4-dimethoxyphenyl)-1-butyl)-N-(4-tert-butyldimethylsiloxyphenyl)amine

TIPSOTf

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