5-(3-(bromomethyl)-4-fluorophenyl)-4-methyl-2-(3-(methylsulfonyl)propoxy)pyridine

Base Information

Chemical Name:5-(3-(bromomethyl)-4-fluorophenyl)-4-methyl-2-(3-(methylsulfonyl)propoxy)pyridine
CAS No.:1544740-62-6
Molecular Formula:C₁₇H₁₉BrFNO₃S
Molecular Weight:416.311
Hs Code.:

Synonyms:5-(3-(bromomethyl)-4-fluorophenyl)-4-methyl-2-(3-(methylsulfonyl)propoxy)pyridine

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Chemical Property of 5-(3-(bromomethyl)-4-fluorophenyl)-4-methyl-2-(3-(methylsulfonyl)propoxy)pyridine

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Technology Process of 5-(3-(bromomethyl)-4-fluorophenyl)-4-methyl-2-(3-(methylsulfonyl)propoxy)pyridine

There total 3 articles about 5-(3-(bromomethyl)-4-fluorophenyl)-4-methyl-2-(3-(methylsulfonyl)propoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872460-12-3
5-(dihydroxyboranyl)-2-fluorobenzoic acid

: 1544740-62-6
5-(3-(bromomethyl)-4-fluorophenyl)-4-methyl-2-(3-(methylsulfonyl)propoxy)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / water; 1,4-dioxane / 0.5 h / 100 °C / Microwave irradiation; Inert atmosphere

2: dimethylsulfide borane complex / tetrahydrofuran / 17 h / 0 - 20 °C

3: phosphorus tribromide / tetrahydrofuran / 17 h / 0 - 20 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; dimethylsulfide borane complex; phosphorus tribromide; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 1544739-29-8
5-bromo-4-methyl-2-(3-(methylsulfonyl)propoxy)pyridine

: 1544740-62-6
5-(3-(bromomethyl)-4-fluorophenyl)-4-methyl-2-(3-(methylsulfonyl)propoxy)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / water; 1,4-dioxane / 0.5 h / 100 °C / Microwave irradiation; Inert atmosphere

2: dimethylsulfide borane complex / tetrahydrofuran / 17 h / 0 - 20 °C

3: phosphorus tribromide / tetrahydrofuran / 17 h / 0 - 20 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; dimethylsulfide borane complex; phosphorus tribromide; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 1544740-60-4
2-fluoro-5-(4-methyl-6-(3-(methylsulfonyl)propoxy)pyridin-3-yl)benzoic acid

: 1544740-62-6
5-(3-(bromomethyl)-4-fluorophenyl)-4-methyl-2-(3-(methylsulfonyl)propoxy)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 17 h / 0 - 20 °C

2: phosphorus tribromide / tetrahydrofuran / 17 h / 0 - 20 °C

With dimethylsulfide borane complex; phosphorus tribromide; In tetrahydrofuran;