3-[<1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl>-7-methoxynaphthalen-2-ylsulfonylamino]-N-propionic acid

Base Information

Chemical Name:3-[<1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl>-7-methoxynaphthalen-2-ylsulfonylamino]-N-propionic acid
CAS No.:186551-19-9
Molecular Formula:C₂₆H₂₅N₃O₆S
Molecular Weight:507.567
Hs Code.:

Synonyms:3-[<1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl>-7-methoxynaphthalen-2-ylsulfonylamino]-N-propionic acid

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Chemical Property of 3-[<1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl>-7-methoxynaphthalen-2-ylsulfonylamino]-N-propionic acid

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Technology Process of 3-[<1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl>-7-methoxynaphthalen-2-ylsulfonylamino]-N-propionic acid

There total 7 articles about 3-[<1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl>-7-methoxynaphthalen-2-ylsulfonylamino]-N-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186551-18-8
3-[<1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl>-7-methoxynaphthalen-2-ylsulfonylamino]-N-propionic acid tert-butyl ester

: 186551-19-9
3-[<1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl>-7-methoxynaphthalen-2-ylsulfonylamino]-N-propionic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 3h;
DOI:10.1021/jm990040h

Reference yield:

: 135-55-7
7-hydroxynaphthalene-2-sulfonic acid sodium salt

: 186551-19-9
3-[<1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl>-7-methoxynaphthalen-2-ylsulfonylamino]-N-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaOH / ethanol / 16 h / 20 °C

2: 3.80 g / POCl₃; PCl₅ / 4 h / 120 °C

3: Et₃N / CH₂Cl₂ / 2 h

4: 0.64 g / K₂CO₃ / dimethylformamide / 24 h / 60 °C

5: CF₃CO₂H / CH₂Cl₂ / 3 h

With sodium hydroxide; phosphorus pentachloride; potassium carbonate; triethylamine; trifluoroacetic acid; trichlorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Methylation / 2: Chlorination / 3: Condensation / 4: Addition / 5: acidolysis;
DOI:10.1021/jm990040h

Reference yield:

: 56875-60-6
7-Methoxy-2-naphthalenesulfonyl chloride

: 186551-19-9
3-[<1-(3-cyanobenzyl)-2-oxopyrrolidin-3-(S)-yl>-7-methoxynaphthalen-2-ylsulfonylamino]-N-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2 h

2: 0.64 g / K₂CO₃ / dimethylformamide / 24 h / 60 °C

3: CF₃CO₂H / CH₂Cl₂ / 3 h

With potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Addition / 3: acidolysis;
DOI:10.1021/jm990040h