2-chloro-N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-4-fluorobenzamide

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Chemical Name:2-chloro-N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-4-fluorobenzamide
CAS No.:1432112-28-1
Molecular Formula:C₂₇H₂₀Cl₂FN₅O₂
Molecular Weight:536.393
Hs Code.:

Synonyms:2-chloro-N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-4-fluorobenzamide

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Chemical Property of 2-chloro-N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-4-fluorobenzamide

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Technology Process of 2-chloro-N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-4-fluorobenzamide

There total 9 articles about 2-chloro-N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 272-52-6
1H-pyrazolo-[4,3-b]-pyridine

: 1432112-28-1
2-chloro-N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: bromine / methanol; water / 0.67 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 4 h / Reflux; Inert atmosphere

4: hydrogenchloride / ethanol / 2 h / Reflux

5: dichloromethane; pyridine / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; pyridine; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 21900-54-9
2-chloro-4-fluorobenzoyl chloride

: 1432112-24-7
2-chloro-N⁴-[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]benzene-1,4-diamine

: 1432112-28-1
2-chloro-N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-4-fluorobenzamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;

Reference yield:

: 121-87-9
2-Chloro-4-nitroaniline

: 1432112-28-1
2-chloro-N-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane; pyridine / 20 °C

2: hydrogenchloride; tin(II) chloride dihdyrate / 2 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 4 h / Reflux; Inert atmosphere

4: hydrogenchloride / ethanol / 2 h / Reflux

5: dichloromethane; pyridine / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tin(II) chloride dihdyrate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; pyridine; ethanol; dichloromethane;