1-⁽¹³⁾C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamine)ethanol hydrochloride

Base Information

• Chemical Name: 1-⁽¹³⁾C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamine)ethanol hydrochloride
• CAS No.: 1319718-90-5
• Molecular Formula: C₁₂H₁₈Cl₂N₂O*ClH
• Molecular Weight: 314.644

Synonyms:1-⁽¹³⁾C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamine)ethanol hydrochloride

Chemical Property of 1-⁽¹³⁾C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamine)ethanol hydrochloride

Chemical Property:

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Technology Process of 1-⁽¹³⁾C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamine)ethanol hydrochloride

There total 6 articles about 1-⁽¹³⁾C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamine)ethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(13)C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamino)ethanone hydrochloride (1319718-89-2) → 1-(13)C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamine)ethanol hydrochloride (1319718-90-5)

Guidance literature:

1-⁽¹³⁾C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamino)ethanone hydrochloride; With sodium tetrahydroborate; sodium hydroxide; In methanol; water; at 20 ℃; for 1h; pH=7;

With hydrogenchloride; In diethyl ether; dichloromethane;

DOI:10.1016/j.tet.2011.05.118

Reference yield:

4'-aminoacetophen[13C-carbonyl]one (861435-57-6) → 1-(13)C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamine)ethanol hydrochloride (1319718-90-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride; N-chloro-succinimide / water / 10 h / 50 °C

2: bromine / dichloromethane / 20 °C

3: chloroform / 24 h / 50 °C

4: sodium tetrahydroborate; sodium hydroxide / methanol; water / 1 h / 20 °C / pH 7

With hydrogenchloride; sodium tetrahydroborate; N-chloro-succinimide; bromine; sodium hydroxide; In methanol; dichloromethane; chloroform; water;

DOI:10.1016/j.tet.2011.05.118

Reference yield:

1-(13)C-4'-amino-2-bromo-3',5'-dichloroacetophenone (1319718-87-0) → 1-(13)C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamine)ethanol hydrochloride (1319718-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroform / 24 h / 50 °C

2: sodium tetrahydroborate; sodium hydroxide / methanol; water / 1 h / 20 °C / pH 7

With sodium tetrahydroborate; sodium hydroxide; In methanol; chloroform; water;

DOI:10.1016/j.tet.2011.05.118

upstream raw materials:

4'-aminoacetophen[13C-carbonyl]one

1-⁽¹³⁾C-4'-amino-2-bromo-3',5'-dichloroacetophenone

1-⁽¹³⁾C-1-(4'-amino-3',5'-dichlorophenyl)-2-(tert-butylamino)ethanone hydrochloride

1-⁽¹³⁾C-4'-acetamidoacetophenone

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