2-(3-methoxy-benzenesulfonyl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

Base Information

Chemical Name:2-(3-methoxy-benzenesulfonyl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline
CAS No.:1350411-17-4
Molecular Formula:C₂₅H₃₃N₃O₃S
Molecular Weight:455.621
Hs Code.:

Synonyms:2-(3-methoxy-benzenesulfonyl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

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Chemical Property of 2-(3-methoxy-benzenesulfonyl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

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Technology Process of 2-(3-methoxy-benzenesulfonyl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

There total 5 articles about 2-(3-methoxy-benzenesulfonyl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 10130-74-2
m-Methoxybenzenesulfonyl chloride

: 1350377-12-6
6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

: 1350411-17-4
2-(3-methoxy-benzenesulfonyl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: With sodium t-butanolate; In toluene; at 35 ℃; for 12h;

Reference yield:

: 58971-11-2
2-(3-bromophenyl)ethanamine

: 1350411-17-4
2-(3-methoxy-benzenesulfonyl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C

2.1: sulfuric acid / toluene; 1,2-dimethoxyethane / 15 h / 50 °C / Inert atmosphere

3.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 85 °C / Inert atmosphere

4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 60 - 85 °C / Inert atmosphere

4.2: 0 °C

5.1: sodium t-butanolate / toluene / 12 h / 35 °C

With triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,2-dimethoxyethane; dichloromethane; toluene;

Reference yield:

: 494833-87-3
N-(3-bromophenethyl)-4-methylbenzenesulfonamide

: 1350411-17-4
2-(3-methoxy-benzenesulfonyl)-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / toluene; 1,2-dimethoxyethane / 15 h / 50 °C / Inert atmosphere

2.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 85 °C / Inert atmosphere

3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 60 - 85 °C / Inert atmosphere

3.2: 0 °C

4.1: sodium t-butanolate / toluene / 12 h / 35 °C

With sodium bis(2-methoxyethoxy)aluminium dihydride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,2-dimethoxyethane; toluene;