2,6-bis(hydroxymethyl)-4-iodophenol

Base Information

• Chemical Name: 2,6-bis(hydroxymethyl)-4-iodophenol
• CAS No.: 263160-71-0
• Molecular Formula: C₈H₉IO₃
• Molecular Weight: 280.062
• Mol file: 263160-71-0.mol

Synonyms:2,6-bis(hydroxymethyl)-4-iodophenol

Chemical Property of 2,6-bis(hydroxymethyl)-4-iodophenol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2,6-bis(hydroxymethyl)-4-iodophenol

There total 4 articles about 2,6-bis(hydroxymethyl)-4-iodophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,6-bis(hydroxymethyl)phenol (2937-59-9) → 2,6-bis(hydroxymethyl)-4-iodophenol (263160-71-0)

Guidance literature:

With sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1002/ejic.201402327

Reference yield:

2-methoxyisophthalic acid (1951-38-8) → 2,6-bis(hydroxymethyl)-4-iodophenol (263160-71-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 24 h / Reflux; Inert atmosphere

2: boron tribromide / dichloromethane / 15 h / -78 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: N,N,N-trimethylbenzenemethanaminium dichloroiodate; sodium hydrogencarbonate / methanol / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; sulfuric acid; boron tribromide; sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/ejic.201402327

Reference yield:

diethyl 2-methoxyisophthalate (107274-63-5) → 2,6-bis(hydroxymethyl)-4-iodophenol (263160-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 15 h / -78 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: N,N,N-trimethylbenzenemethanaminium dichloroiodate; sodium hydrogencarbonate / methanol / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; boron tribromide; sodium hydrogencarbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/ejic.201402327

upstream raw materials:

2,6-bis(hydroxymethyl)phenol

2-methoxyisophthalic acid

diethyl 2-methoxyisophthalate

Downstream raw materials:

4-iodo-2,6-bis(trimethylsilyloxymethyl)phenol trimethylsilyl ether