4-[4-(benzyloxy)phenyl]-1,2,3,6-tetrahydropyridine

Base Information

• Chemical Name: 4-[4-(benzyloxy)phenyl]-1,2,3,6-tetrahydropyridine
• CAS No.: 778642-53-8
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 265.355
• Mol file: 778642-53-8.mol

Synonyms:4-{4-[(phenylmethyl)oxy]phenyl}-1,2,3,6-tetrahydropyridine

Chemical Property of 4-[4-(benzyloxy)phenyl]-1,2,3,6-tetrahydropyridine

Chemical Property:

Purity/Quality:

4-[4-(Benzyloxy)phenyl]-1,2,3,6-tetrahydropyridine ^*data from reagent suppliers

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-[4-(benzyloxy)phenyl]-1,2,3,6-tetrahydropyridine

There total 1 articles about 4-[4-(benzyloxy)phenyl]-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1,1-dimethylethyl 4-hydroxy-4-{4-[(phenylmethyl)oxy]phenyl}-1-piperidinecarboxylate (302924-63-6) → 4-{4-[(phenylmethyl)oxy]phenyl}-1,2,3,6-tetrahydropyridine (778642-53-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield: 34.0%

tetrahydro-2H-pyran-4-carboxylic acid (5337-03-1) + 4-{4-[(phenylmethyl)oxy]phenyl}-1,2,3,6-tetrahydropyridine (778642-53-8) → 4-{4-[(phenylmethyl)oxy]phenyl}-1-(tetrahydro-2H-pyran-4-ylcarbonyl)-1,2,3,6-tetrahydropyridine (778642-54-9)

Guidance literature:

tetrahydro-2H-pyran-4-carboxylic acid; With oxalyl dichloride; In DMF (N,N-dimethyl-formamide); dichloromethane; at 20 ℃; for 3h;

4-{4-[(phenylmethyl)oxy]phenyl}-1,2,3,6-tetrahydropyridine; With triethylamine; In dichloromethane; for 1h;

upstream raw materials:

1,1-dimethylethyl 4-hydroxy-4-{4-[(phenylmethyl)oxy]phenyl}-1-piperidinecarboxylate

Downstream raw materials:

4-{4-[(phenylmethyl)oxy]phenyl}-1-(tetrahydro-2H-pyran-4-ylcarbonyl)-1,2,3,6-tetrahydropyridine

Refernces