(2R,3S,4R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-phenyl-pentanoic acid methylamide

Base Information

Chemical Name:(2R,3S,4R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-phenyl-pentanoic acid methylamide
CAS No.:136137-90-1
Molecular Formula:C₂₄H₄₅NO₄Si₂
Molecular Weight:467.797
Hs Code.:

Synonyms:(2R,3S,4R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-phenyl-pentanoic acid methylamide

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Chemical Property of (2R,3S,4R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-phenyl-pentanoic acid methylamide

Chemical Property:

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Technology Process of (2R,3S,4R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-phenyl-pentanoic acid methylamide

There total 4 articles about (2R,3S,4R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-phenyl-pentanoic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3R,4R)-5-Benzyl-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-1-methyl-pyrrolidin-2-one

: 136137-90-1
(2R,3S,4R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-phenyl-pentanoic acid methylamide

: 136137-94-5
(2R,3S,4S)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-phenyl-pentanoic acid methylamide

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)92719-9

Reference yield:

: 75534-70-2
(3R,4R)-3,4-dihydroxy-1-methylpyrrolidine-2,5-dione

: 136137-90-1
(2R,3S,4R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-phenyl-pentanoic acid methylamide

Guidance literature:: Multi-step reaction with 4 steps

2: 1) acetyl chloride / 1) EtOH; or with R₃SiOSO₂CF₃

3: tetrahydrofuran / -78 - 0 °C

4: NaBH₄ / ethanol / 0 - 20 °C

With sodium tetrahydroborate; acetyl chloride; In tetrahydrofuran; ethanol;
DOI:10.1016/S0040-4039(00)92719-9

Reference yield:

: 136137-81-0
(3R,4R)-4-(acetyloxy)-1-methyl-2,5-dioxopyrrolidin-3-yl acetate

: 136137-90-1
(2R,3S,4R)-2,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-5-phenyl-pentanoic acid methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1) acetyl chloride / 1) EtOH; or with R₃SiOSO₂CF₃

2: tetrahydrofuran / -78 - 0 °C

3: NaBH₄ / ethanol / 0 - 20 °C

With sodium tetrahydroborate; acetyl chloride; In tetrahydrofuran; ethanol;
DOI:10.1016/S0040-4039(00)92719-9