O⁵-(tert-Butyl)-O¹-Methyl (R)-N²-<(Benzyloxy)carbonyl>-2-methylglutamate

Base Information

Chemical Name:O⁵-(tert-Butyl)-O¹-Methyl (R)-N²-<(Benzyloxy)carbonyl>-2-methylglutamate
CAS No.:135924-04-8
Molecular Formula:C₁₉H₂₇NO₆
Molecular Weight:365.426
Hs Code.:

O<sup>5</sup>-(tert-Butyl)-O<sup>1</sup>-Methyl (R)-N<sup>2</sup>-<(Benzyloxy)carbonyl>-2-methylglutamate

Synonyms:O⁵-(tert-Butyl)-O¹-Methyl (R)-N²-<(Benzyloxy)carbonyl>-2-methylglutamate

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Chemical Property of O⁵-(tert-Butyl)-O¹-Methyl (R)-N²-<(Benzyloxy)carbonyl>-2-methylglutamate

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Technology Process of O⁵-(tert-Butyl)-O¹-Methyl (R)-N²-<(Benzyloxy)carbonyl>-2-methylglutamate

There total 3 articles about O⁵-(tert-Butyl)-O¹-Methyl (R)-N²-<(Benzyloxy)carbonyl>-2-methylglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 135947-69-2
(2S,4R)-3-<(Benzyloxy)carbonyl>-4-(<(tert-butyloxy)carbonyl>ethyl)-4-methyl-2-phenyl-1,3-oxazolidin-5-one

: 135924-04-8
O⁵-(tert-Butyl)-O¹-Methyl (R)-N²-<(Benzyloxy)carbonyl>-2-methylglutamate

Guidance literature:: With lithium hydroxide; In methanol; for 0.5h; Ambient temperature;
DOI:10.1002/hlca.19910740414

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 135924-04-8
O⁵-(tert-Butyl)-O¹-Methyl (R)-N²-<(Benzyloxy)carbonyl>-2-methylglutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) (i-Pr)2NH, BuLi / 1) THF, -78 deg C, 10 min., 2) a) -78 deg C, 3 h, b) r.t., overnight

2: 78 percent / 4N aq. LiOH / methanol / 0.5 h / Ambient temperature

With lithium hydroxide; n-butyllithium; diisopropylamine; In methanol;
DOI:10.1002/hlca.19910740414

Reference yield:

: 135923-87-4
(2S,4R)-3-<(Benzyloxy)carbonyl>-4-methyl-2-phenyl-1,3-oxazolidin-5-one

: 135924-04-8
O⁵-(tert-Butyl)-O¹-Methyl (R)-N²-<(Benzyloxy)carbonyl>-2-methylglutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) (i-Pr)2NH, BuLi / 1) THF, -78 deg C, 10 min., 2) a) -78 deg C, 3 h, b) r.t., overnight

2: 78 percent / 4N aq. LiOH / methanol / 0.5 h / Ambient temperature

With lithium hydroxide; n-butyllithium; diisopropylamine; In methanol;
DOI:10.1002/hlca.19910740414