(R)-methyl 2-amino-3-(4-tolyl)propanoate

Base Information

• Chemical Name: (R)-methyl 2-amino-3-(4-tolyl)propanoate
• CAS No.: 196107-03-6
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 196107-03-6.mol

Synonyms:(R)-methyl 2-amino-3-(4-tolyl)propanoate

Chemical Property of (R)-methyl 2-amino-3-(4-tolyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-methyl 2-amino-3-(4-tolyl)propanoate

There total 7 articles about (R)-methyl 2-amino-3-(4-tolyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Z)-2-chloro-3-(4-cyanophenyl)acrylic acid methyl ester (1323412-89-0) → (R)-methyl 2-amino-3-(4-tolyl)propanoate (196107-03-6)

Guidance literature:

Multi-step reaction with 4 steps

1: D-glucose / ethanol; water / 72 h / 30 °C / Microbiological reaction

2: thionyl chloride / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 60 °C

4: palladium 10% on activated carbon; hydrogen / ethyl acetate

With thionyl chloride; sodium azide; D-glucose; palladium 10% on activated carbon; hydrogen; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201100537

Reference yield:

(R)-2-((tert-butoxycarbonyl)amino)-3-(p-tolyl)propanoic acid (80102-27-8) → (R)-methyl 2-amino-3-(4-tolyl)propanoate (196107-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0.5 h

2: sulfuric acid / dichloromethane; trifluoroacetic acid / 2 h / Reflux

With sulfuric acid; trifluoroacetic acid; In dichloromethane; trifluoroacetic acid;

DOI:10.1039/c3ob40215k

Reference yield:

(S)-2-chloro-3-(4-cyanophenyl)propanoic acid (1323412-94-7) → (R)-methyl 2-amino-3-(4-tolyl)propanoate (196107-03-6)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 20 °C

2: sodium azide / N,N-dimethyl-formamide / 60 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate

With thionyl chloride; sodium azide; palladium 10% on activated carbon; hydrogen; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201100537

upstream raw materials:

(Z)-2-chloro-3-(4-cyanophenyl)acrylic acid methyl ester

(S)-2-chloro-3-(4-cyanophenyl)propanoic acid

(S)-methyl 2-chloro-3-(4-cyanophenyl)propanoate

(R)-methyl 2-azido-3-(4-cyanophenyl)propanoate

Downstream raw materials:

(R)-methyl 2-amino-3-(4-tolyl)propanoate hydrochloride

N-(N-benzoyl-L-tryptophanyl)-para-methyl-D-phenylalanine methyl ester