exo-(1R,5S)-3-[4-((5S)-5-{[(dichloroacetyl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

Base Information

Chemical Name:exo-(1R,5S)-3-[4-((5S)-5-{[(dichloroacetyl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid
CAS No.:681424-36-2
Molecular Formula:C₁₈H₁₇Cl₂F₂N₃O₅
Molecular Weight:464.253
Hs Code.:

Synonyms:exo-(1R,5S)-3-[4-((5S)-5-{[(dichloroacetyl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

Suppliers and Price of exo-(1R,5S)-3-[4-((5S)-5-{[(dichloroacetyl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of exo-(1R,5S)-3-[4-((5S)-5-{[(dichloroacetyl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of exo-(1R,5S)-3-[4-((5S)-5-{[(dichloroacetyl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

There total 11 articles about exo-(1R,5S)-3-[4-((5S)-5-{[(dichloroacetyl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 681424-99-7
(S)-(1α,5α,6α)-3-(4-{5-[(2,2,-dichloroacetylamino)methyl]-2-oxooxazolidin-3-yl}-2,6-difluorophenyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester

: 681424-36-2
exo-(1R,5S)-3-[4-((5S)-5-{[(dichloroacetyl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm058204j

Reference yield:

: 681424-87-3
(1α,5α,6α)-3-benzyloxycarbonyl-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester

: 681424-36-2
exo-(1R,5S)-3-[4-((5S)-5-{[(dichloroacetyl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: 0.423 g / H₂ / Pd(OH)2/C / methanol / 1.5 h

2.1: 92 percent / diisopropylethylamine / dimethylformamide / 20 h / 50 °C

3.1: Fe; aq. NH₄Cl / ethanol / 1.5 h / Heating

4.1: 0.71 g / pyridine / CH₂Cl₂ / 0 - 20 °C

5.1: lithium hexamethyldisilylamide / tetrahydrofuran / 1.5 h / -78 °C

5.2: 87 percent / tetrahydrofuran / 16 h / 20 °C

6.1: 99 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

7.1: NaN₃ / dimethylformamide / 15 h / 70 °C

8.1: PPh₃ / tetrahydrofuran / 3 h / 20 °C

8.2: 86 percent / H₂O / tetrahydrofuran / 16 h / 40 °C

9.1: 62 percent / pyridine / dimethylformamide / 16 h / 20 °C

10.1: 89 percent / TFA / CH₂Cl₂ / 3 h / 20 °C

With pyridine; sodium azide; hydrogen; iron; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm058204j

Reference yield:

: 681424-89-5
(1α,5α,6α)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid tert-butyl ester

: 681424-36-2
exo-(1R,5S)-3-[4-((5S)-5-{[(dichloroacetyl)amino]methyl}-2-oxo-1,3-oxazolidin-3-yl)-2,6-difluorophenyl]-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: 92 percent / diisopropylethylamine / dimethylformamide / 20 h / 50 °C

2.1: Fe; aq. NH₄Cl / ethanol / 1.5 h / Heating

3.1: 0.71 g / pyridine / CH₂Cl₂ / 0 - 20 °C

4.1: lithium hexamethyldisilylamide / tetrahydrofuran / 1.5 h / -78 °C

4.2: 87 percent / tetrahydrofuran / 16 h / 20 °C

5.1: 99 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 °C

6.1: NaN₃ / dimethylformamide / 15 h / 70 °C

7.1: PPh₃ / tetrahydrofuran / 3 h / 20 °C

7.2: 86 percent / H₂O / tetrahydrofuran / 16 h / 40 °C

8.1: 62 percent / pyridine / dimethylformamide / 16 h / 20 °C

9.1: 89 percent / TFA / CH₂Cl₂ / 3 h / 20 °C

With pyridine; sodium azide; iron; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm058204j