[(S)-1-[4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carbonyl]-5-(3-o-tolyl-ureido)-pentyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(S)-1-[4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carbonyl]-5-(3-o-tolyl-ureido)-pentyl]-carbamic acid tert-butyl ester
CAS No.:157973-96-1
Molecular Formula:C₃₃H₄₆N₆O₆
Molecular Weight:622.765
Hs Code.:

Synonyms:[(S)-1-[4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carbonyl]-5-(3-o-tolyl-ureido)-pentyl]-carbamic acid tert-butyl ester

Suppliers and Price of [(S)-1-[4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carbonyl]-5-(3-o-tolyl-ureido)-pentyl]-carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(S)-1-[4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carbonyl]-5-(3-o-tolyl-ureido)-pentyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(S)-1-[4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carbonyl]-5-(3-o-tolyl-ureido)-pentyl]-carbamic acid tert-butyl ester

There total 10 articles about [(S)-1-[4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carbonyl]-5-(3-o-tolyl-ureido)-pentyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 131451-45-1
2-(S)-<<(tert-butyloxy)carbonyl>amino>-6-(3-o-tolylureido)hexanoic acid

: 157973-95-0
(S)-2-(7-Oxo-[1,4]diazepan-1-yl)-3-phenyl-propionamide

: 157973-96-1
[(S)-1-[4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carbonyl]-5-(3-o-tolyl-ureido)-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00037a005

Reference yield:

: 5241-58-7
L-Phenylalanine amide

: 157973-96-1
[(S)-1-[4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carbonyl]-5-(3-o-tolyl-ureido)-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) AcOH, 2.) sodium cyanoborohydride / 1.) CH₃CN, RT, 20 min, 2.) CH₃CN, RT, overnight

2: K₂CO₃ / methanol; H₂O / 3 h / Heating

3: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

4: 70 percent / H₂ / 10percent Pd/C / ethanol / 16 h / 760 Torr

5: 65 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

With hydrogen; sodium cyanoborohydride; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm00037a005

Reference yield:

: 10494-76-5
3-(2-hydroxyethylamino)propionic acid methyl ester

: 157973-96-1
[(S)-1-[4-((S)-1-Carbamoyl-2-phenyl-ethyl)-5-oxo-[1,4]diazepane-1-carbonyl]-5-(3-o-tolyl-ureido)-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: aq. NaHCO₃, 1 N aq. NaOH / tetrahydrofuran / Ambient temperature

2: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) CH₂Cl₂, -78 deg C, 10 min

3: 1.) AcOH, 2.) sodium cyanoborohydride / 1.) CH₃CN, RT, 20 min, 2.) CH₃CN, RT, overnight

4: K₂CO₃ / methanol; H₂O / 3 h / Heating

5: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

6: 70 percent / H₂ / 10percent Pd/C / ethanol / 16 h / 760 Torr

7: 65 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; oxalyl dichloride; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm00037a005