α-acetamido-3,4,5-trimethoxycinnamic acid

Base Information

• Chemical Name: α-acetamido-3,4,5-trimethoxycinnamic acid
• CAS No.: 87293-13-8
• Molecular Formula: C₁₄H₁₇NO₆
• Molecular Weight: 295.292
• Mol file: 87293-13-8.mol

Synonyms:α-acetamido-3,4,5-trimethoxycinnamic acid

Chemical Property of α-acetamido-3,4,5-trimethoxycinnamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-acetamido-3,4,5-trimethoxycinnamic acid

There total 3 articles about α-acetamido-3,4,5-trimethoxycinnamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-methyl-4-(3,4,5-trimethoxyphenylmethylene)-5(4H)-oxazolone (92249-24-6) → α-acetamido-3,4,5-trimethoxycinnamic acid (87293-13-8)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 0.5h;

DOI:10.1080/00397910701265895

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → α-acetamido-3,4,5-trimethoxycinnamic acid (87293-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium acetate; acetic anhydride / 0.5 h / 20 °C

1.2: 92 percent / 5 h / 60 °C

2.1: 96 percent / aq. sodium hydroxide / methanol / 0.5 h / 20 °C

With sodium hydroxide; sodium acetate; acetic anhydride; In methanol;

DOI:10.1080/00397910701265895

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → α-acetamido-3,4,5-trimethoxycinnamic acid (87293-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / NaOAc, Ac₂O / 8 h / 120 °C

2: 95 percent / 0.2 N HCl / 1 h / 90 °C

With hydrogenchloride; sodium acetate; acetic anhydride;

DOI:10.1055/s-1992-26228

upstream raw materials:

2-methyl-4-(3,4,5-trimethoxyphenylmethylene)-5(4H)-oxazolone

3,4,5-trimethoxy-benzaldehyde

Downstream raw materials:

2-Hydroxy-3-(3,4,5-trimethoxy-phenyl)-propionic acid

(Z)-2-Hydroxy-3-(3,4,5-trimethoxy-phenyl)-acrylic acid

N-Acetyl-3.4.5-trimethoxyphenylalanin

2-Amino-3-(3,4,5-trimethoxy-phenyl)-propionic acid; hydrochloride

Refernces

• 1、 Wong,Xu,Chang,Lee. "A modified synthesis of (±)-β-aryllactic acids". . p. 793 - 797. Retrieved 2007/10/02.