Methyl [5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-YL]acetate

Base Information

Chemical Name:Methyl [5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-YL]acetate
CAS No.:157169-68-1
Molecular Formula:C14H15 N O3
Molecular Weight:245.278
Hs Code.:
DSSTox Substance ID:DTXSID00440806
Wikidata:Q82257224
Mol file:157169-68-1.mol

Synonyms:157169-68-1;METHYL [5-METHYL-2-(4-METHYLPHENYL)-1,3-OXAZOL-4-YL]ACETATE;Methyl 2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]acetate;Methyl 2-(5-methyl-2-(p-tolyl)oxazol-4-yl)acetate;methyl 2-(5-methyl-2-p-tolyloxazol-4-yl)acetate;SCHEMBL821081;DTXSID00440806;FQPFECCIWLWKER-UHFFFAOYSA-N;AKOS015910715;4-Oxazoleacetic acid,5-methyl-2-(4-methylphenyl)-,methyl ester

Suppliers and Price of Methyl [5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-YL]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
METHYL-[5-METHYL-2-(4-METHYLPHENYL)-1,3-OXAZOL-4-YL]ACETATE 95.00%
5MG
$ 503.84

Total 5 raw suppliers

Chemical Property of Methyl [5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-YL]acetate

Chemical Property:

Melting Point:71 °C
Boiling Point:368.8±44.0 °C(Predicted)
PKA:0?+-.0.26(Predicted)
PSA：52.33000
Density:1.135±0.06 g/cm3(Predicted)
LogP:2.67390
XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:245.10519334
Heavy Atom Count:18
Complexity:287

Purity/Quality:

99% ^*data from raw suppliers

METHYL-[5-METHYL-2-(4-METHYLPHENYL)-1,3-OXAZOL-4-YL]ACETATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=NC(=C(O2)C)CC(=O)OC

Technology Process of Methyl [5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-YL]acetate

There total 8 articles about Methyl [5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-YL]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 496060-65-2
3-acetyl-3-(4-methylbenzoylamino)propanoic acid methyl ester

: 157169-68-1
2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)acetic acid methyl ester

Guidance literature:: With sodium hydroxide; sulfuric acid; In acetic anhydride;

Reference yield: 85.0%

: 439803-74-4
2-(4-methylbenzoylamino)butane-1,4-dioic acid 4-methyl ester

: 108-24-7
acetic anhydride

: 157169-68-1
2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)acetic acid methyl ester

Guidance literature:: 2-(4-methylbenzoylamino)butane-1,4-dioic acid 4-methyl ester; acetic anhydride; With pyridine; at 20 - 55 ℃; for 8.33333h;

With sulfuric acid; In pyridine; at 20 - 88 ℃; for 3.66667h;

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 157169-68-1
2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane; triethylamine / dichloromethane / 1 h / 5 - 25 °C

1.2: 16 h / 10 - 20 °C

2.1: dmap; pyridine / 2 h / 90 °C

3.1: acetic anhydride; sulfuric acid / 80 °C

With pyridine; dmap; chloro-trimethyl-silane; sulfuric acid; acetic anhydride; triethylamine; In dichloromethane;