Diethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(diethoxyphosphoryl)ethylphosphonate

Base Information

Chemical Name:Diethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(diethoxyphosphoryl)ethylphosphonate
CAS No.:925684-68-0
Molecular Formula:C₁₈H₃₀BrNO₇P₂
Molecular Weight:514.29
Hs Code.:

Synonyms:Diethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(diethoxyphosphoryl)ethylphosphonate

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Chemical Property of Diethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(diethoxyphosphoryl)ethylphosphonate

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Technology Process of Diethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(diethoxyphosphoryl)ethylphosphonate

There total 1 articles about Diethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(diethoxyphosphoryl)ethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 925684-68-0
Diethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(diethoxyphosphoryl)ethylphosphonate

Guidance literature:

Reference yield: 51.0%

: 925684-68-0
Diethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(diethoxyphosphoryl)ethylphosphonate

: 925684-93-1
Benzyl 1-cyclopropyl-6-fluoro-1,4-dihydro-7-((4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl)-8-methoxy-4-oxoquinoline-3-carboxylate

: 124-38-9,18923-20-1
carbon dioxide

: 925684-94-2
benzyl 7-((4aS,7aS)-1-(((4-(2,2-bis(diethylphosphono)ethyl)phenylcarbamoyl)methoxy)carbonyl)-octahydropyrrolo[3,4-b]pyridin-6-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 20.5h;

Reference yield:

: 925684-68-0
Diethyl 2-{4-[(bromoacetyl)amino]phenyl}-1-(diethoxyphosphoryl)ethylphosphonate

: 925684-31-7
7-((4aS,7aS)-1-(((4-(2,2-bisphosphonoethyl)phenylcarbamoyl)methoxy)carbonyl)-octahydropyrrolo[3,4-b]pyridin-6-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 20.5 h / 20 °C

2.1: cyclohexene / palladium 10% on activated carbon / ethanol / 20 h / Heating / reflux

3.1: trimethylsilyl bromide / dichloromethane / 20 °C

3.2: pH 7.1

With trimethylsilyl bromide; caesium carbonate; cyclohexene; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide;