4-BROMO-2-HYDROXYBENZONITRILE

Base Information

• Chemical Name: 4-BROMO-2-HYDROXYBENZONITRILE
• CAS No.: 288067-35-6
• Molecular Formula: C7H4BrNO
• Molecular Weight: 198.019
• Hs Code.: 2926909090
• Mol file: 288067-35-6.mol

Synonyms:2-Hydroxy-4-bromobenzonitrile;4-Bromo-2-hydroxybenzonitrile;

Chemical Property of 4-BROMO-2-HYDROXYBENZONITRILE

Chemical Property:

• Vapor Pressure: 0.000883mmHg at 25°C
• Melting Point: 160 °C
• Refractive Index: 1.656
• Boiling Point: 295.1 °C at 760 mmHg
• PKA: 6.20±0.10(Predicted)
• Flash Point: 132.3 °C
• PSA: 44.02000
• Density: 1.79 g/cm³
• LogP: 2.02638
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.5% ^*data from raw suppliers

4-Bromo-2-hydroxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-2-HYDROXYBENZONITRILE

There total 7 articles about 4-BROMO-2-HYDROXYBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

4-bromo-2-methoxybenzonitrile (330793-38-9) → 4-bromo-2-hydroxy-benzonitrile (288067-35-6)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; Heating / reflux;

Reference yield: 85.0%

4-bromo-6-fluorobenzonitrile (105942-08-3) → 4-bromo-2-hydroxy-benzonitrile (288067-35-6)

Guidance literature:

With 2-(methylsulfonyl)ethyl alcohol; sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1081/SCC-120028347

Reference yield: 81.0%

5-Bromo-2-fluoro-benzonitrile (179897-89-3) → 4-bromo-2-hydroxy-benzonitrile (288067-35-6)

Guidance literature:

With sodium hydroxide; potassium acetate; 18-crown-6 ether; In ethyl acetate; acetonitrile;

upstream raw materials:

4-bromo-6-fluorobenzonitrile

4-bromo-2-methoxybenzonitrile

5-Bromo-2-fluoro-benzonitrile

3-Bromophenol

Downstream raw materials:

2-(benzyloxy)-4-bromobenzonitrile

Refernces

• 1、 Revuelto, Alejandro,Ruiz-Santaquiteria, Marta,De Lucio, Héctor,Gamo, Ana,Carriles, Alejandra A.,Gutiérrez, Kilian Jesús,Sánchez-Murcia, Pedro A.,Hermoso, Juan A.,Gago, Federico,Camarasa, María-José,Jiménez-Ruiz, Antonio,Velázquez, Sonsoles. "Pyrrolopyrimidine vs Imidazole-Phenyl-Thiazole Scaffolds in Nonpeptidic Dimerization Inhibitors of Leishmania infantum Trypanothione Reductase". . p. 873 - 891. Retrieved 2019/05/16.
• 2、 El Bialy, Serry A.A.,Abd El Kader, Kamelia F.,Boykin, David W.. "Synthesis of benzyloxycyanophenylboronic esters". experimental part. p. 10 - 16. Retrieved 2011/10/18.