methyl 2-(2-amino-3-pyridyl)-1-[2-(1-cyclohexenyl)ethyl]-1H-benzo[d]imidazole-5-carboxylate

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Chemical Name:methyl 2-(2-amino-3-pyridyl)-1-[2-(1-cyclohexenyl)ethyl]-1H-benzo[d]imidazole-5-carboxylate
CAS No.:1430101-83-9
Molecular Formula:C₂₂H₂₄N₄O₂
Molecular Weight:376.458
Hs Code.:

Synonyms:methyl 2-(2-amino-3-pyridyl)-1-[2-(1-cyclohexenyl)ethyl]-1H-benzo[d]imidazole-5-carboxylate

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Chemical Property of methyl 2-(2-amino-3-pyridyl)-1-[2-(1-cyclohexenyl)ethyl]-1H-benzo[d]imidazole-5-carboxylate

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Technology Process of methyl 2-(2-amino-3-pyridyl)-1-[2-(1-cyclohexenyl)ethyl]-1H-benzo[d]imidazole-5-carboxylate

There total 5 articles about methyl 2-(2-amino-3-pyridyl)-1-[2-(1-cyclohexenyl)ethyl]-1H-benzo[d]imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430101-79-3
methyl 3-[(2-amino-3-pyridyl)carbonyl]amino-4-[2-(1-cyclohexenyl)ethyl]aminobenzoate

: 1430101-83-9
methyl 2-(2-amino-3-pyridyl)-1-[2-(1-cyclohexenyl)ethyl]-1H-benzo[d]imidazole-5-carboxylate

Guidance literature:: With magnesium sulfate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 130 ℃; for 0.166667h; Microwave irradiation; Inert atmosphere;
DOI:10.1021/co400010y

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1430101-83-9
methyl 2-(2-amino-3-pyridyl)-1-[2-(1-cyclohexenyl)ethyl]-1H-benzo[d]imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 0.17 h / 80 °C / Microwave irradiation; Inert atmosphere

2: zinc; ammonium formate / methanol / 0.08 h / 90 °C / Microwave irradiation; Inert atmosphere

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h / 160 °C / Microwave irradiation; Inert atmosphere

4: trifluoroacetic acid; magnesium sulfate / 1,2-dichloro-ethane / 0.17 h / 130 °C / Microwave irradiation; Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium formate; magnesium sulfate; triethylamine; trifluoroacetic acid; zinc; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/co400010y

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1430101-83-9
methyl 2-(2-amino-3-pyridyl)-1-[2-(1-cyclohexenyl)ethyl]-1H-benzo[d]imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 0.25 h / 80 °C / Microwave irradiation; Inert atmosphere

2: dichloromethane / 0.17 h / 80 °C / Microwave irradiation; Inert atmosphere

3: zinc; ammonium formate / methanol / 0.08 h / 90 °C / Microwave irradiation; Inert atmosphere

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h / 160 °C / Microwave irradiation; Inert atmosphere

5: trifluoroacetic acid; magnesium sulfate / 1,2-dichloro-ethane / 0.17 h / 130 °C / Microwave irradiation; Inert atmosphere

With sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium formate; magnesium sulfate; triethylamine; trifluoroacetic acid; zinc; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/co400010y