BIS[2-(P-NITROPHENYL)ETHYL] PHOSPHOROCHLORIDATE

Base Information

• Chemical Name: BIS[2-(P-NITROPHENYL)ETHYL] PHOSPHOROCHLORIDATE
• CAS No.: 85363-77-5
• Molecular Formula: C16H16 Cl N2 O7 P
• Molecular Weight: 414.73
• Hs Code.: 2931900090
• Mol file: 85363-77-5.mol

Synonyms:Bis[2-(p-nitrophenyl)ethyl]phosphorochloridate

Chemical Property of BIS[2-(P-NITROPHENYL)ETHYL] PHOSPHOROCHLORIDATE

Chemical Property:

• PSA: 136.98000
• LogP: 5.71470
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BIS[2-(P-NITROPHENYL)ETHYL] PHOSPHOROCHLORIDATE

There total 1 articles about BIS[2-(P-NITROPHENYL)ETHYL] PHOSPHOROCHLORIDATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

bis(p-nitrophenylethyl)phosphite (85363-76-4) → bis<2-(p-nitrophenyl)ethyl> phosphorochloridate (85363-77-5)

Guidance literature:

With sulfuryl dichloride; In tetrachloromethane; dichloromethane; for 0.25h;

DOI:10.1002/hlca.19870700508

Reference yield: 91.0%

bis<2-(p-nitrophenyl)ethyl> phosphorochloridate (85363-77-5) + N2-isobutyryl5'-O-monomethoxytrityl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine (91592-86-8) → N2-isobutyryl-5'-O-monomethoxytrityl-O6-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate) (115222-29-2)

Guidance literature:

With pyridine; 1-methyl-1H-imidazole; for 4h; Ambient temperature;

DOI:10.1002/hlca.19870700508

Reference yield: 90.0%

bis<2-(p-nitrophenyl)ethyl> phosphorochloridate (85363-77-5) + 6-N-Benzoyl-5'-O-(4-methoxyphenyl)diphenylmethyl-2'-desoxyadenosin (24816-13-5) → N6-benzoyl-5'-O-monomethoxytrityl-2'-deoxyadenosine 3'(bis<2-(p-nitrophenyl)ethyl> phosphate) (115222-25-8)

Guidance literature:

With pyridine; 1-methyl-1H-imidazole; for 12h; Ambient temperature;

DOI:10.1002/hlca.19870700508

upstream raw materials:

bis(p-nitrophenylethyl)phosphite

Downstream raw materials:

N²-isobutyryl-5'-O-monomethoxytrityl-O⁶-<2-(p-nitrophenyl)ethyl>-2'-deoxyguanosine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)

N⁶-<2-(p-nitrophenyl)ethoxycarbonyl>-3'deoxyadenosine 2',5'-bis(bis<2-(p-nitrophenyl)ethyl> phosphate)

5'-O-(monomethoxytrityl)thimidine 3'-(bis<2-(p-nitrophenyl)ethyl>phosphate)

N⁴-benzoyl-5'-O-monomethoxytrityl-2'-deoxycytidine 3'-(bis<2-(p-nitrophenyl)ethyl> phosphate)