(2S,4aS,5R,8aR)-1-Benzoyl-5-methyl-2-propyldecahydroquinolin-6-one

Base Information

Chemical Name:(2S,4aS,5R,8aR)-1-Benzoyl-5-methyl-2-propyldecahydroquinolin-6-one
CAS No.:160728-68-7
Molecular Formula:C₂₀H₂₇NO₂
Molecular Weight:313.44
Hs Code.:

Synonyms:(2S,4aS,5R,8aR)-1-Benzoyl-5-methyl-2-propyldecahydroquinolin-6-one

Suppliers and Price of (2S,4aS,5R,8aR)-1-Benzoyl-5-methyl-2-propyldecahydroquinolin-6-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4aS,5R,8aR)-1-Benzoyl-5-methyl-2-propyldecahydroquinolin-6-one

Chemical Property:

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Technology Process of (2S,4aS,5R,8aR)-1-Benzoyl-5-methyl-2-propyldecahydroquinolin-6-one

There total 17 articles about (2S,4aS,5R,8aR)-1-Benzoyl-5-methyl-2-propyldecahydroquinolin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 160728-67-6
(2S,8aR)-1-Benzoyl-5-methyl-2-propyl-1,2,3,4,6,7,8,8a-octahydroquinolin-6-one

: 160728-68-7
(2S,4aS,5R,8aR)-1-Benzoyl-5-methyl-2-propyldecahydroquinolin-6-one

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; Ambient temperature;
DOI:10.1016/0040-4039(94)88469-2

Reference yield:

: 7348-72-3
trans-Pent-2-enyl(triphenyl)phosphonium bromide

: 160728-68-7
(2S,4aS,5R,8aR)-1-Benzoyl-5-methyl-2-propyldecahydroquinolin-6-one

Guidance literature:: Multi-step reaction with 17 steps

1: 95 percent / t-BuOK / tetrahydrofuran / 1.) r.t., 20 min, 2.) r.t., 5 min

2: 1.) DIBALH, 2.) I₂ / 1.) CH₂Cl₂, hexane, r.t., 1 h, 2.) benzene, irradiation, 15 min

3: 95 percent / pyridine / 4 h / 0 °C

4: 93 percent / dimethylsulfoxide / 1 h / 55 °C

5: 84 percent / 25percent aq. NaOH / methanol / 9 h / Heating

6: 88 percent / diethyl ether / 0.25 h / 0 °C

7: 89 percent / KOH, NH₂OH*HCl / methanol / 1.) 0 deg C, 5 min, 2.) 0 deg C, 30 min

8: aq. Pr₄NIO₄ / methanol / 0.5 h / 0 °C

9: 100 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 0.5 h

10: 2.) NaBH₃CN / 1.) THF, 0 deg C, 1 h, 2.) 0 deg C, 30 min

11: 91 percent / Zn, 85percent aq. AcOH / 1 h / 60 °C

12: 98 percent / 10percent aq. K₂CO₃ / CH₂Cl₂ / 2 h / 0 °C

13: 99 percent / H₂ / 10percent Pd/C / methanol / 0.5 h

14: 74 percent / PCC, 3 Angstroem molecular sieves / CH₂Cl₂ / 2 h / Ambient temperature

15: 74 percent / KOH / ethanol / 0.17 h / 0 °C

16: 50 percent / aq. KHSO₄ / methanol / 48 h / Ambient temperature

17: 71 percent / H₂, aq HCl / 10percent Pd/C / methanol / 0.5 h

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; potassium hydrogensulfate; tetrapropylammonium periodate; 3 A molecular sieve; hydroxylamine hydrochloride; potassium tert-butylate; hydrogen; iodine; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; acetic acid; pyridinium chlorochromate; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/P19960001113

Reference yield:

: (2S,4S)-4-(Hexa-1,3-dienyl)-2-phenyl-1,3-dioxane

: 160728-68-7
(2S,4aS,5R,8aR)-1-Benzoyl-5-methyl-2-propyldecahydroquinolin-6-one

Guidance literature:: Multi-step reaction with 16 steps

1: 1.) DIBALH, 2.) I₂ / 1.) CH₂Cl₂, hexane, r.t., 1 h, 2.) benzene, irradiation, 15 min

2: 95 percent / pyridine / 4 h / 0 °C

3: 93 percent / dimethylsulfoxide / 1 h / 55 °C

4: 84 percent / 25percent aq. NaOH / methanol / 9 h / Heating

5: 88 percent / diethyl ether / 0.25 h / 0 °C

6: 89 percent / KOH, NH₂OH*HCl / methanol / 1.) 0 deg C, 5 min, 2.) 0 deg C, 30 min

7: aq. Pr₄NIO₄ / methanol / 0.5 h / 0 °C

8: 100 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 0.5 h

9: 2.) NaBH₃CN / 1.) THF, 0 deg C, 1 h, 2.) 0 deg C, 30 min

10: 91 percent / Zn, 85percent aq. AcOH / 1 h / 60 °C

11: 98 percent / 10percent aq. K₂CO₃ / CH₂Cl₂ / 2 h / 0 °C

12: 99 percent / H₂ / 10percent Pd/C / methanol / 0.5 h

13: 74 percent / PCC, 3 Angstroem molecular sieves / CH₂Cl₂ / 2 h / Ambient temperature

14: 74 percent / KOH / ethanol / 0.17 h / 0 °C

15: 50 percent / aq. KHSO₄ / methanol / 48 h / Ambient temperature

16: 71 percent / H₂, aq HCl / 10percent Pd/C / methanol / 0.5 h

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; potassium hydrogensulfate; tetrapropylammonium periodate; 3 A molecular sieve; hydroxylamine hydrochloride; hydrogen; iodine; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; acetic acid; pyridinium chlorochromate; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/P19960001113