(6R,7R)-4-diphenylmethoxycarbonyl-3-methyl-7-phenoxyacetamidoceph-3-em 1,1-dioxide

Base Information

• Chemical Name: (6R,7R)-4-diphenylmethoxycarbonyl-3-methyl-7-phenoxyacetamidoceph-3-em 1,1-dioxide
• CAS No.: 103194-75-8
• Molecular Formula: C₂₉H₂₆N₂O₇S
• Molecular Weight: 546.601
• Mol file: 103194-75-8.mol

Synonyms:(6R,7R)-4-diphenylmethoxycarbonyl-3-methyl-7-phenoxyacetamidoceph-3-em 1,1-dioxide

Chemical Property of (6R,7R)-4-diphenylmethoxycarbonyl-3-methyl-7-phenoxyacetamidoceph-3-em 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R,7R)-4-diphenylmethoxycarbonyl-3-methyl-7-phenoxyacetamidoceph-3-em 1,1-dioxide

There total 1 articles about (6R,7R)-4-diphenylmethoxycarbonyl-3-methyl-7-phenoxyacetamidoceph-3-em 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

diphenylmethyl (6R,7R)-3-methyl-7β-phenoxyacetamidoceph-3-em-4-carboxylate (10209-10-6) → (6R,7R)-4-diphenylmethoxycarbonyl-3-methyl-7-phenoxyacetamidoceph-3-em 1,1-dioxide (103194-75-8)

Guidance literature:

With formic acid; dihydrogen peroxide; In dichloromethane; water; for 44h;

Reference yield: 60.0%

(6R,7R)-4-diphenylmethoxycarbonyl-3-methyl-7-phenoxyacetamidoceph-3-em 1,1-dioxide (103194-75-8) → (2R,6R,7R)-2-Hydroxy-3-methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ6-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid benzhydryl ester (103194-76-9)

Guidance literature:

palladium on activated charcoal; In ethyl acetate;

DOI:10.1039/c39860000165

Reference yield: 54.0%

(6R,7R)-4-diphenylmethoxycarbonyl-3-methyl-7-phenoxyacetamidoceph-3-em 1,1-dioxide (103194-75-8) + acrylonitrile (107-13-1,25014-41-9) → diphenylmethyl (6R,7R)-2.2-bis(2'-cyanoethyl)-3-methyl-7β-phenoxyacetamidoceph-3-em-4-carboxylate 1,1-dioxide (134830-11-8)

Guidance literature:

With triethylamine; for 20h; Ambient temperature;

upstream raw materials:

diphenylmethyl (6R,7R)-3-methyl-7β-phenoxyacetamidoceph-3-em-4-carboxylate

Downstream raw materials:

(6R,7R)-3-Methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(2R,6R,7R)-2-Hydroxy-3-methyl-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2-carboxylic acid benzhydryl ester

diphenylmethyl (6R,7R)-2.2-bis(2'-cyanoethyl)-3-methyl-7β-phenoxyacetamidoceph-3-em-4-carboxylate 1,1-dioxide

diphenylmethyl 2-<(2R,3R)-2-acetonylsulphonyl-4-oxo-3-phenoxyacetamidoazetidin-1-yl>glyoxylate