(1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine

Base Information

• Chemical Name: (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine
• CAS No.: 252279-09-7
• Molecular Formula: C₁₉H₁₈N₄
• Molecular Weight: 302.379
• Mol file: 252279-09-7.mol

Synonyms:(1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine

Chemical Property of (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine

There total 6 articles about (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl[(1R)-2-(1H-indol-3-yl)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]carbamate (335243-50-0) → (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine (252279-09-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

DOI:10.1016/S0960-894X(01)00107-X

Reference yield:

Boc-D-Trp-OH (5241-64-5) → (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine (252279-09-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: aq. Cs₂CO₃ / dimethylformamide

1.2: dimethylformamide

2.1: ammonium acetate / xylene / Heating

3.1: 3 N HCl / ethyl acetate

With ammonium acetate; hydrogenchloride; caesium carbonate; In ethyl acetate; N,N-dimethyl-formamide; xylene;

DOI:10.1016/S0960-894X(01)00107-X

Reference yield:

benzyl (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate (335243-53-3) → (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine (252279-09-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0960-894X(01)00107-X

upstream raw materials:

tert-butyl[(1R)-2-(1H-indol-3-yl)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]carbamate

benzyl (1R)-2-(1H-indol-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

Boc-D-Trp-OH

2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-oxo-2-phenyl-ethyl ester

Downstream raw materials:

C₂₆H₂₉N₅O₂S

(1S,3R)-3-(4-phenyl-1H-imidazol-2-yl)-1-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carboline

(1R,3R)-3-(4-phenyl-1H-imidazol-2-yl)-1-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carboline

C₂₇H₂₉N₅O₂