(S)-2-((S)-1-{(S)-1-[(S)-2-Benzyloxy-1-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-5-benzyloxycarbonylamino-pentylcarbamoyl}-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(S)-2-((S)-1-{(S)-1-[(S)-2-Benzyloxy-1-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-5-benzyloxycarbonylamino-pentylcarbamoyl}-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:123347-80-8
Molecular Formula:C₄₇H₆₂N₆O₁₁
Molecular Weight:887.043
Hs Code.:

(S)-2-((S)-1-{(S)-1-[(S)-2-Benzyloxy-1-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-5-benzyloxycarbonylamino-pentylcarbamoyl}-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:(S)-2-((S)-1-{(S)-1-[(S)-2-Benzyloxy-1-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-5-benzyloxycarbonylamino-pentylcarbamoyl}-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-2-((S)-1-{(S)-1-[(S)-2-Benzyloxy-1-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-5-benzyloxycarbonylamino-pentylcarbamoyl}-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-2-((S)-1-{(S)-1-[(S)-2-Benzyloxy-1-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-5-benzyloxycarbonylamino-pentylcarbamoyl}-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 9 articles about (S)-2-((S)-1-{(S)-1-[(S)-2-Benzyloxy-1-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-5-benzyloxycarbonylamino-pentylcarbamoyl}-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: (S)-Pyrrolidine-2-carboxylic acid benzotriazol-1-yl ester

: (S)-2-{(S)-2-[(S)-2-((S)-2-Amino-propionylamino)-6-benzyloxycarbonylamino-hexanoylamino]-3-benzyloxy-propionylamino}-propionic acid benzyl ester

: 123347-80-8
(S)-2-((S)-1-{(S)-1-[(S)-2-Benzyloxy-1-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-5-benzyloxycarbonylamino-pentylcarbamoyl}-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 123347-80-8
(S)-2-((S)-1-{(S)-1-[(S)-2-Benzyloxy-1-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-5-benzyloxycarbonylamino-pentylcarbamoyl}-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DCC / dimethylformamide / 1. 0 deg C, 1 h, 2. room temperature, 1 h

2: 92 percent / N-methylmorpholine / dimethylformamide / 24 h / Ambient temperature

With 4-methyl-morpholine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

Reference yield:

: 23680-31-1
BOC-O-benzyl-L-serine

: 123347-80-8
(S)-2-((S)-1-{(S)-1-[(S)-2-Benzyloxy-1-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-ethylcarbamoyl]-5-benzyloxycarbonylamino-pentylcarbamoyl}-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1. N-methylmorpholine, isobutyl chloroformate; 2. N-methylmorpholine / 1. DMF, -10 deg C, 4 min; 2. room temperature, 4 h

2: CF₃COOH / 0.5 h / Ambient temperature

3: 58 percent / N-methylmorpholine / dimethylformamide / 4 h / Ambient temperature

4: acetic acid; trifluoroacetic acid / 0.5 h / Ambient temperature

5: 80 percent / EEDQ / dimethylformamide / 24 h

6: acetic acid; trifluoroacetic acid / 0.5 h / Ambient temperature

7: 92 percent / N-methylmorpholine / dimethylformamide / 24 h / Ambient temperature

With 4-methyl-morpholine; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; trifluoroacetic acid; isobutyl chloroformate; In acetic acid; N,N-dimethyl-formamide; trifluoroacetic acid;