2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1H-indole

Base Information

Chemical Name:2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1H-indole
CAS No.:1314595-76-0
Molecular Formula:C₂₂H₂₃NO₃
Molecular Weight:349.43
Hs Code.:

Synonyms:2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1H-indole

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Chemical Property of 2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1H-indole

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Technology Process of 2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1H-indole

There total 6 articles about 2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1314595-75-9
2-(3-(((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)prop-1-yn-1-yl)aniline

: 1314595-77-1
(2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-ol

: 1314595-76-0
2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1H-indole

Guidance literature:: With platinum(II) chloride; In nitromethane; at 0 - 40 ℃; Inert atmosphere;
DOI:10.1021/ol201532k

Reference yield:

: 615-43-0
2-iodophenylamine

: 1314595-76-0
2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 2 h / 50 °C / Inert atmosphere

2: platinum(II) chloride / nitromethane / 0 - 40 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; platinum(II) chloride; In nitromethane; 1: Sonogashira coupling;
DOI:10.1021/ol201532k

Reference yield:

: C₁₅H₂₂O₃Si

: 1314595-77-1
(2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-ol

: 1314595-76-0
2-((((2R,3S,6S)-2-(methoxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl)oxy)methyl)-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 2 h / 50 °C / Inert atmosphere

5.1: platinum(II) chloride / nitromethane / 0 - 40 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; sodium hydride; diethylamine; platinum(II) chloride; In tetrahydrofuran; nitromethane; mineral oil; 4.1: Sonogashira coupling;
DOI:10.1021/ol201532k