4-{[5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl]ethynyl}benzenesulfonamide

Base Information

Chemical Name:4-{[5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl]ethynyl}benzenesulfonamide
CAS No.:1356998-38-3
Molecular Formula:C₁₃H₁₃N₃O₃S
Molecular Weight:291.331
Hs Code.:

Synonyms:4-{[5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl]ethynyl}benzenesulfonamide

Suppliers and Price of 4-{[5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl]ethynyl}benzenesulfonamide

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Chemical Property of 4-{[5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl]ethynyl}benzenesulfonamide

Chemical Property:

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Technology Process of 4-{[5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl]ethynyl}benzenesulfonamide

There total 3 articles about 4-{[5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl]ethynyl}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356998-36-1
4-[(5-formyl-1-methyl-1H-pyrazol-4-yl)ethynyl]benzenesulfonamide

: 1356998-38-3
4-{[5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl]ethynyl}benzenesulfonamide

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

: 4-iodo-1-methyl-1H-pyrazole-5-carboxaldehyde

: 1356998-38-3
4-{[5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl]ethynyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 80 °C

2: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 764638-11-1
p-ethynylbenzene sulfonic acid

: 1356998-38-3
4-{[5-(hydroxymethyl)-1-methyl-1H-pyrazol-4-yl]ethynyl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 80 °C

2: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;