4-methoxyphenyl (S)-2-fluoro-2,3-diphenylpropanoate

Base Information

Chemical Name:4-methoxyphenyl (S)-2-fluoro-2,3-diphenylpropanoate
CAS No.:1588768-28-8
Molecular Formula:C₂₂H₁₉FO₃
Molecular Weight:350.389
Hs Code.:

Synonyms:4-methoxyphenyl (S)-2-fluoro-2,3-diphenylpropanoate

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Chemical Property of 4-methoxyphenyl (S)-2-fluoro-2,3-diphenylpropanoate

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Technology Process of 4-methoxyphenyl (S)-2-fluoro-2,3-diphenylpropanoate

There total 4 articles about 4-methoxyphenyl (S)-2-fluoro-2,3-diphenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1588767-56-9
(S)-2-fluoro-1-(4-methoxyphenyl)-2,3-diphenylpropan-1-one

: 1588768-28-8
4-methoxyphenyl (S)-2-fluoro-2,3-diphenylpropanoate

Guidance literature:: With 1,1,1,3',3',3'-hexafluoro-propanol; 3-chloro-benzenecarboperoxoic acid; In aq. phosphate buffer; dichloromethane; at 20 ℃; for 36h; regioselective reaction; Inert atmosphere;
DOI:10.1021/ja501815p

Reference yield:

: 5739-38-8
1-(4-methoxyphenyl)-3-phenylpropan-1-one

: 1588768-28-8
4-methoxyphenyl (S)-2-fluoro-2,3-diphenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 1.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: triethylamine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

3.1: (1,2-dimethoxyethane)dichloronickel(II); 2,2′-methylene bis[(4R,5S)-4,5-diphenyl-2-oxazoline] / tetrahydrofuran; diethylene glycol dimethyl ether / 0.42 h / -25 °C / Inert atmosphere

3.2: 36 h / -25 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid; 1,1,1,3',3',3'-hexafluoro-propanol / dichloromethane; aq. phosphate buffer / 36 h / 20 °C / Inert atmosphere

With n-butyllithium; (1,2-dimethoxyethane)dichloronickel(II); 1,1,1,3',3',3'-hexafluoro-propanol; trimethylsilyl trifluoromethanesulfonate; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; 2,2′-methylene bis[(4R,5S)-4,5-diphenyl-2-oxazoline]; In tetrahydrofuran; aq. phosphate buffer; hexane; dichloromethane; diethylene glycol dimethyl ether; 3.2: |Negishi Coupling / 4.1: |Baeyer-Villiger Ketone Oxidation;
DOI:10.1021/ja501815p

Reference yield:

: 1588765-63-2
C₁₆H₁₅FO₂

: 1588768-28-8
4-methoxyphenyl (S)-2-fluoro-2,3-diphenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: (1,2-dimethoxyethane)dichloronickel(II); 2,2′-methylene bis[(4R,5S)-4,5-diphenyl-2-oxazoline] / tetrahydrofuran; diethylene glycol dimethyl ether / 0.42 h / -25 °C / Inert atmosphere

2.2: 36 h / -25 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid; 1,1,1,3',3',3'-hexafluoro-propanol / dichloromethane; aq. phosphate buffer / 36 h / 20 °C / Inert atmosphere

With (1,2-dimethoxyethane)dichloronickel(II); 1,1,1,3',3',3'-hexafluoro-propanol; trimethylsilyl trifluoromethanesulfonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,2′-methylene bis[(4R,5S)-4,5-diphenyl-2-oxazoline]; In tetrahydrofuran; aq. phosphate buffer; dichloromethane; diethylene glycol dimethyl ether; 2.2: |Negishi Coupling / 3.1: |Baeyer-Villiger Ketone Oxidation;
DOI:10.1021/ja501815p