Technology Process of methyl 3α,12α-diacetoxy-5β-chol-6-en-24-oate
There total 1 articles about methyl 3α,12α-diacetoxy-5β-chol-6-en-24-oate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / Reflux
2.1: pyridine / dmap / dichloromethane / 12 h / 20 °C
3.1: bromine; acetic acid / 48 h / 20 °C
4.1: zinc(II) tetrahydroborate / benzene; diethyl ether / 22 h / 20 °C
4.2: 1 h / Reflux
With
pyridine; hydrogenchloride; zinc(II) tetrahydroborate; bromine; acetic acid;
dmap;
In
diethyl ether; dichloromethane; benzene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 69 percent / N-bromoacetamide, 0.46M aq. HClO4, / dioxane / 0.25 h / 4 °C
2: 91 percent / Pb(OAc)4, I2, CaCO3 / benzene; cyclohexane / 0.33 h / 80 °C / Irradiation
3: 70 percent / Zn, CH3COOH / diethyl ether / 0.5 h / 100 °C
4: 82 percent / pyridine / 3 h
5: 94 percent / m-chloroperbenzoic acid / CH2Cl2 / 4 h
6: 71 percent / HBr, CH3COOH / CH2Cl2 / 2 h / Ambient temperature
7: 88 percent / Raney-Ni, EtOH, CH3COOH / 0.17 h / Heating
8: 70 percent / KOH / methanol / 12 h / Heating
With
pyridine; lead(IV) acetate; potassium hydroxide; perchloric acid; ethanol; hydrogen bromide; iodine; nickel; acetic acid; 3-chloro-benzenecarboperoxoic acid; calcium carbonate; zinc; N-bromoacetamide;
In
1,4-dioxane; methanol; diethyl ether; dichloromethane; cyclohexane; benzene;
DOI:10.1248/cpb.43.1551
