15-keto-prostaglandin E2

Base Information

• Chemical Name: 15-keto-prostaglandin E2
• CAS No.: 26441-05-4
• Molecular Formula: C20H30O5
• Molecular Weight: 350.455
• UNII: 2S0F1FTK13
• ChEMBL ID: CHEMBL1447369
• DSSTox Substance ID: DTXSID401317991
• Metabolomics Workbench ID: 2396
• Nikkaji Number: J346.055J
• Wikidata: Q27098095
• Mol file: 26441-05-4.mol

Synonyms:15-keto-PGE2;15-keto-prostaglandin E2;15-ketoprostaglandin E2;15-ketoprostaglandin E2, (11alpha)-isomer;15-oxo-PGE2;9,15-dioxo-11-hydroxyprosta-5,13-dienoic acid

Chemical Property of 15-keto-prostaglandin E2

Chemical Property:

• Vapor Pressure: 1.19E-13mmHg at 25°C
• Refractive Index: 1.552
• Boiling Point: 534.4 °C at 760 mmHg
• PKA: 4.75±0.10(Predicted)
• Flash Point: 291 °C
• PSA: 91.67000
• Density: 1.144 g/cm³
• LogP: 3.45930
• Storage Temp.: −20°C
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 12
• Exact Mass: 350.20932405
• Heavy Atom Count: 25
• Complexity: 506

Purity/Quality:

99% ^*data from raw suppliers

15-KetoProstaglandinE2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCC(=O)C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O
• Isomeric SMILES: CCCCCC(=O)/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O
• General Description: 15-KETO PROSTAGLANDIN E2 (15-Keto PGE2) is a metabolite formed through the oxidation of prostaglandin E2 (PGE2) by 15-hydroxyprostaglandin dehydrogenase (15-PGDH), which reduces its biological activity. This conversion is part of the catabolic pathway of prostaglandins, involving the hydrogen bonding of the C-15 hydroxyl group of PGE2 to residues such as Gln-148 in 15-PGDH, facilitating the reaction. Additionally, 15-Keto PGE2 can also be derived from an alternative biosynthetic pathway involving 15-hydroperoxy-PGE2, identified in both mammalian and algal systems, suggesting its broader metabolic and regulatory roles in inflammation and immune responses.

Technology Process of 15-keto-prostaglandin E2

There total 3 articles about 15-keto-prostaglandin E2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

15-hydroperoxy-PGE2 → dinoprostone (363-24-6) + 15-Oxoprostaglandin E2 (26441-05-4,914804-63-0)

Guidance literature:

With methanol; sodium tetrahydroborate; at 37 ℃; for 24h; Temperature;

DOI:10.1002/anie.201910461

Reference yield:

dinoprostone (363-24-6) → 15-Oxoprostaglandin E2 (26441-05-4,914804-63-0)

Guidance literature:

With hydrogenchloride; nicotinamide adenine dinucleotide; 2-amino-2-hydroxymethyl-1,3-propanediol; 15-hydroxyprostaglandin dehydrogenase; In water; at 37 ℃; pH=7.5; Further Variations:; Catalysts; Kinetics; Enzyme kinetics;

DOI:10.1016/j.bmc.2006.06.030

Reference yield:

→ 15-Oxoprostaglandin E2 (26441-05-4,914804-63-0)

Guidance literature:

Verb. 1b, CrO3;

DOI:10.1021/jo00951a043

upstream raw materials:

dinoprostone

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 26441-05-4 15-KETO PROSTAGLANDIN E2

Send

Send

Metric Ton KG G Pound L ML

Send

Send