Leukotriene A3 methyl ester

Base Information

Chemical Name:Leukotriene A3 methyl ester
CAS No.:83851-38-1
Molecular Formula:C₂₁H₃₄O₃
Molecular Weight:334.499
Hs Code.:2918990090
European Community (EC) Number:632-884-4
Wikidata:Q76511231
Mol file:83851-38-1.mol

Synonyms:Leukotriene A3 methyl ester;83851-38-1;methyl 4-[(2S,3S)-3-[(1E,3E,5Z)-tetradeca-1,3,5-trienyl]oxiran-2-yl]butanoate;MFCD00065894;AKOS040755936;SR-01000946884;SR-01000946884-1;Leukotriene A3 methyl ester, ~50 mug/mL in hexane: diethyl ether: triethylamine (95:5:0.5), >=95% (HPLC)

Suppliers and Price of Leukotriene A3 methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
LTA3(LeukotrieneA3methylester)
100μg
$ 235.00

Cayman Chemical
Leukotriene A3 methyl ester ≥97%
25μg
$ 85.00

American Custom Chemicals Corporation
LEUKOTRIENE A3 METHYL ESTER 97.00%
1MG
$ 2686.53

Total 8 raw suppliers

Chemical Property of Leukotriene A3 methyl ester

Chemical Property:

Vapor Pressure:6.59E-08mmHg at 25°C
Boiling Point:439°C at 760 mmHg
Flash Point:-26 °C
PSA：38.83000
Density:0.985g/cm³
LogP:5.51630
Storage Temp.:−20°C
XLogP3:6.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:15
Exact Mass:334.25079494
Heavy Atom Count:24
Complexity:409

Purity/Quality:

99% ^*data from raw suppliers

LTA3(LeukotrieneA3methylester) ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,Xn,N
Hazard Codes:F,Xn,N
Statements: 11-38-48/20-51/53-62-65-67
Safety Statements: 36/37-61-62-16

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCCCC=CC=CC=CC1C(O1)CCCC(=O)OC
Isomeric SMILES:CCCCCCCC/C=C\C=C\C=C\[C@H]1[C@@H](O1)CCCC(=O)OC
Description Biosynthesis of LTA3 occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway and it is the putative intermediate in the biosynthesis of 3-series leukotrienes. LTA3 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
Uses LTA3 (Leukotriene A3 methyl ester) is a suicide inhibitor of LTA4 hydrolase.

Technology Process of Leukotriene A3 methyl ester

There total 4 articles about Leukotriene A3 methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 54208-05-8
n-nonylidene triphenylphosphorane

: 79356-67-5
4-[(2R,3S)-3-((1E,3E)-5-Oxo-penta-1,3-dienyl)-oxiranyl]-butyric acid methyl ester

: 83851-38-1,84237-37-6,89496-14-0
Leukotriene A₃

Guidance literature:: In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃;
DOI:10.1002/ardp.19833160911

Reference yield:

: 73427-12-0
(+)-(S,R-trans)-3-formyloxiranebutanoic acid methyl ester

: 83851-38-1
methyl 5(S),6(S)-oxido-7(E),9(E),11(Z)-eicosatrienoate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / benzene / 1.5 h / 60 °C

2: 1.) n-butyllithium, 2.) Et₃N, MsCl / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 h

3: tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / 0 °C

With n-butyllithium; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; benzene;
DOI:10.1248/cpb.30.2453

Reference yield:

: 73958-01-7
methyl 8-formyl-5(S),6(S)-oxido-7(E)-octenoate

: 83851-38-1
methyl 5(S),6(S)-oxido-7(E),9(E),11(Z)-eicosatrienoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-butyllithium, 2.) Et₃N, MsCl / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, -78 deg C, 1 h

2: tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / 0 °C

With n-butyllithium; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1248/cpb.30.2453