N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine

Base Information

Chemical Name:N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
CAS No.:690206-97-4
Molecular Formula:C₁₆H₁₃ClFN₃O₂
Molecular Weight:333.75
Hs Code.:
DSSTox Substance ID:DTXSID90416176
Nikkaji Number:J1.265.526F
Wikidata:Q27089298
Pharos Ligand ID:XBZU91PUYX63
ChEMBL ID:CHEMBL150315
Mol file:690206-97-4.mol

Synonyms:4-((4'-chloro-2'-fluoro)phenylamino)-6,7-dimethoxyquinazoline;CB676475

Suppliers and Price of N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ZM306416
100mg
$ 1365.00

TRC
ZM213689DisodiumSalt(Meropenemimpurity)(Mixtureofdoublebondisomers)
10mg
$ 140.00

Tocris
ZM-306416 hydrochloride ≥99%(HPLC)
1
$ 91.00

Tocris
ZM-306416 hydrochloride ≥99%(HPLC)
10
$ 193.00

Medical Isotopes, Inc.
ZM306416
100 mg
$ 2240.00

Medical Isotopes, Inc.
ZM 306416
10 mg
$ 655.00

Medical Isotopes, Inc.
ZM213689DisodiumSalt(Meropenemimpurity)(Mixtureofdoublebondisomers)
10 mg
$ 640.00

Medical Isotopes, Inc.
ZM306416
2.5 mg
$ 625.00

DC Chemicals
ZM306416 >98%
100 mg
$ 400.00

Crysdot
ZM-306416(CB676475) 98+%
50mg
$ 429.00

Total 31 raw suppliers

Chemical Property of N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine

Chemical Property:

Vapor Pressure:6.97E-09mmHg at 25°C
Boiling Point:460.5°C at 760 mmHg
Flash Point:232.3°C
PSA：56.27000
LogP:4.25610
Storage Temp.:Desiccate at RT
Solubility.:Methanol (Slightly), Water (Sparingly)
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:333.0680325
Heavy Atom Count:23
Complexity:392

Purity/Quality:

99%, ^*data from raw suppliers

ZM306416 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)C(=NC=N2)NC3=C(C=C(C=C3)Cl)F)OC
Uses ZM-306416 is a VEGFR inhibitor, inhibiting Src, VEGFR1 and Abl with IC50 of 0.33 μM, 0.33 μM and 1.3 μM, respectively. ZM 306416 an inhibitor of tyrosine kinase RTK signaling pathway involved in anti-cancer agents. Anti-tumor, anti-metastatic agent. The major metabolite of Meropenem (M225620) - a carbapenem antibiotic - in plasma and urine. This metabolite existed as a mixture of 1-pyrroline and its 2-pyrroline isomer, and the coexistence of the two isomers at equilibrium in aqueous solutions was observed by NMR.

Technology Process of N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine

There total 1 articles about N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: