tert-butyl 6-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

Base Information

Chemical Name:tert-butyl 6-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate
CAS No.:1262008-41-2
Molecular Formula:C₂₉H₂₆F₃N₅O₆
Molecular Weight:597.551
Hs Code.:

tert-butyl 6-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

Synonyms:tert-butyl 6-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

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Chemical Property of tert-butyl 6-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

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Technology Process of tert-butyl 6-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

There total 5 articles about tert-butyl 6-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 453565-91-8
3-cyano-5-(trifluoromethoxy)benzoic acid

: 1262008-37-6
tert-butyl 6-(N'-hydroxycarbamimidoyl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

: 1262008-41-2
tert-butyl 6-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

Guidance literature:: tert-butyl 6-(N'-hydroxycarbamimidoyl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate; With 1,1'-carbonyldiimidazole; In ISOPROPYLAMIDE; at 60 ℃; for 0.5h;

3-cyano-5-(trifluoromethoxy)benzoic acid; With 2-hydroxypyridin; In ISOPROPYLAMIDE; at 90 ℃; for 3h;

Reference yield:

: methyl 2-(6-bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)acetate hydrochloride

: 1262008-41-2
tert-butyl 6-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 6 h / 20 °C

2.1: zinc; palladium(II) trifluoroacetate; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl / ISOPROPYLAMIDE / 16 h / 100 °C

3.1: hydroxylamine / ethanol; water / 5 h / 70 °C

4.1: 1,1'-carbonyldiimidazole / ISOPROPYLAMIDE / 0.5 h / 60 °C

4.2: 3 h / 90 °C

With hydroxylamine; triethylamine; 1,1'-carbonyldiimidazole; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium(II) trifluoroacetate; zinc; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; water;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1262008-41-2
tert-butyl 6-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-1-(2-methoxy-2-oxoethyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 6 h / 20 °C

2.1: zinc; palladium(II) trifluoroacetate; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl / ISOPROPYLAMIDE / 16 h / 100 °C

3.1: hydroxylamine / ethanol; water / 5 h / 70 °C

4.1: 1,1'-carbonyldiimidazole / ISOPROPYLAMIDE / 0.5 h / 60 °C

4.2: 3 h / 90 °C

With hydroxylamine; triethylamine; 1,1'-carbonyldiimidazole; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; palladium(II) trifluoroacetate; zinc; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; water;