(R)-1-(2-pivaloylpterin-6-yl)-3-<(tert-butyldimethylsilyl)oxy>-4-(benzyloxy)but-1-yne

Base Information

Chemical Name:(R)-1-(2-pivaloylpterin-6-yl)-3-<(tert-butyldimethylsilyl)oxy>-4-(benzyloxy)but-1-yne
CAS No.:131864-04-5
Molecular Formula:C₂₈H₃₇N₅O₄Si
Molecular Weight:535.718
Hs Code.:

Synonyms:(R)-1-(2-pivaloylpterin-6-yl)-3-<(tert-butyldimethylsilyl)oxy>-4-(benzyloxy)but-1-yne

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Chemical Property of (R)-1-(2-pivaloylpterin-6-yl)-3-<(tert-butyldimethylsilyl)oxy>-4-(benzyloxy)but-1-yne

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Technology Process of (R)-1-(2-pivaloylpterin-6-yl)-3-<(tert-butyldimethylsilyl)oxy>-4-(benzyloxy)but-1-yne

There total 1 articles about (R)-1-(2-pivaloylpterin-6-yl)-3-<(tert-butyldimethylsilyl)oxy>-4-(benzyloxy)but-1-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 131864-03-4
(R)-3-<(tert-butyldimethylsilyl)oxy>-4-(benzyloxy)but-1-yne

: 108473-08-1
N-(6-chloro-4-oxo-3,4-dihydropteridin-2-yl)-2,2-dimethylpropanamide

: 131864-04-5
(R)-1-(2-pivaloylpterin-6-yl)-3-<(tert-butyldimethylsilyl)oxy>-4-(benzyloxy)but-1-yne

Guidance literature:: With palladium diacetate; copper(l) iodide; triethylamine; triphenylphosphine; In acetonitrile; for 1h; Heating;
DOI:10.1021/jo00005a029

Reference yield: 99.0%

: 131864-04-5
(R)-1-(2-pivaloylpterin-6-yl)-3-<(tert-butyldimethylsilyl)oxy>-4-(benzyloxy)but-1-yne

: 131864-05-6
(R)-1-(2-pivaloylpterin-6-yl)-4-(benzyloxy)but-1-yn-3-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;
DOI:10.1021/jo00005a029

Reference yield:

: 131864-04-5
(R)-1-(2-pivaloylpterin-6-yl)-3-<(tert-butyldimethylsilyl)oxy>-4-(benzyloxy)but-1-yne

: 131864-06-7
1-(2-pivaloylpterin-6-yl)-4-(benzyloxy)but-1-yn-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h

2: CrO₃, 25percent aq. H₂SO₄ / butan-2-one / 0.5 h / 0 °C

With chromium(VI) oxide; sulfuric acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; butanone;
DOI:10.1021/jo00005a029