N-carboxy Boc-Phe-ΔLeu anhydride

Base Information

• Chemical Name: N-carboxy Boc-Phe-ΔLeu anhydride
• CAS No.: 113378-38-4
• Molecular Formula: C₂₁H₂₆N₂O₆
• Molecular Weight: 402.447
• Mol file: 113378-38-4.mol

Synonyms:N-carboxy Boc-Phe-ΔLeu anhydride

Chemical Property of N-carboxy Boc-Phe-ΔLeu anhydride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-carboxy Boc-Phe-ΔLeu anhydride

There total 1 articles about N-carboxy Boc-Phe-ΔLeu anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-isobutylidene-oxazolidine-2,5-dione (80465-33-4) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → N-carboxy Boc-Phe-ΔLeu anhydride (113378-38-4)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide; In dichloromethane; at -10 - 20 ℃; for 13h;

DOI:10.3987/R-1987-08-2087

Reference yield:

N-carboxy Boc-Phe-ΔLeu anhydride (113378-38-4) → N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 20 °C

2: 2-mercaptoethanol; McIlvaine buffer / papain (EC 3.4.22.2) / 24 h / 35 °C / pH 8.0

With McIlvaine buffer; triethylamine; 2-hydroxyethanethiol; papain (EC 3.4.22.2); In dichloromethane; 1: Condensation / 2: Hydrolysis;

DOI:10.1246/bcsj.70.1427

Reference yield:

L-Alanine methyl ester (10065-72-2) + N-carboxy Boc-Phe-ΔLeu anhydride (113378-38-4) → Boc-Phe-ΔLeu-Ala-OMe (193069-39-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1246/bcsj.70.1427

upstream raw materials:

4-isobutylidene-oxazolidine-2,5-dione

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

3-Benzyl-6-[2-methyl-prop-(E)-ylidene]-piperazine-2,5-dione

Boc-Phe-ΔLeu-Ala-OMe

N-tert-butoxycarbonyl-L-phenylalanine