N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine triethylammonium salt

Base Information

• Chemical Name: N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine triethylammonium salt
• CAS No.: 1162655-66-4
• Molecular Formula: C₆H₁₅N*C₃₃H₄₃N₆O₈PSi
• Molecular Weight: 811.991
• Mol file: 1162655-66-4.mol

Synonyms:N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine triethylammonium salt

Chemical Property of N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine triethylammonium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine triethylammonium salt

There total 1 articles about N₆-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine triethylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

N-benzyloxycarbonyl-1-aminoethanephosphonic acid methyl monoester (61989-17-1) + N6-benzoyl-5′-O-(tert-butyldimethylsilyl)-2′-deoxyadenosine (51549-39-4) + triethylamine (121-44-8) → N6-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine triethylammonium salt (1162655-66-4)

Guidance literature:

N-benzyloxycarbonyl-1-aminoethanephosphonic acid methyl monoester; N⁶-benzoyl-5′-O-(tert-butyldimethylsilyl)-2′-deoxyadenosine; With pyridine; dicyclohexyl-carbodiimide; at 20 ℃; for 144h;

triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.bmc.2009.03.028

Reference yield:

N6-benzoyl-5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine triethylammonium salt (1162655-66-4) → 5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine triethylammonium salt (1162655-68-6)

Guidance literature:

With ammonium hydroxide; water; In methanol; at 20 ℃;

DOI:10.1016/j.bmc.2009.03.028

upstream raw materials:

N-benzyloxycarbonyl-1-aminoethanephosphonic acid methyl monoester

N⁶-benzoyl-5′-O-(tert-butyldimethylsilyl)-2′-deoxyadenosine

triethylamine

Downstream raw materials:

5'-(tert-butyldimethylsilyl)-3'-(1-(benzyloxycarbonylamino)ethyl phosphonyl)-2'-deoxyadenosine triethylammonium salt