{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester

Base Information

Chemical Name:{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester
CAS No.:1415812-30-4
Molecular Formula:C₃₃H₃₆FN₅O₄S
Molecular Weight:617.744
Hs Code.:

Synonyms:{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester

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Chemical Property of {2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester

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Technology Process of {2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester

There total 3 articles about {2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 774-50-5
5-(4-fluorophenyl)thiazol-2-ylamine

: 1415812-29-1
C₂₄H₃₀ClN₃O₄

: 1415812-30-4
{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In water; toluene; for 16h; Inert atmosphere; Reflux;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1415812-30-4
{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; palladium diacetate; tricyclohexylphosphine / N,N-dimethyl-formamide / 1 h / 140 °C / Microwave irradiation; Inert atmosphere

2: hydrogenchloride / water; 1,4-dioxane / 6 h / Reflux

3: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium carbonate / water; toluene / 16 h / Inert atmosphere; Reflux

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium phosphate; palladium diacetate; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tricyclohexylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 73040-69-4
N-(5-(4-fluorophenyl)thiazol-2-yl)acetamide

: 1415812-30-4
{2-[5-(4-fluorophenyl)thiazol-2-ylamino]pyridin-4-ylmethyl}[1,4]diazepane-1,4-icarboxylic acid 1-benzyl ester 4-tertbutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water; 1,4-dioxane / 6 h / Reflux

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium carbonate / water; toluene / 16 h / Inert atmosphere; Reflux

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; toluene;