Acetic acid 5-hydroxy-2,6,6-trimethyl-cyclohex-1-enylmethyl ester

Base Information

• Chemical Name: Acetic acid 5-hydroxy-2,6,6-trimethyl-cyclohex-1-enylmethyl ester
• CAS No.: 199177-36-1
• Molecular Formula: C₁₂H₂₀O₃
• Molecular Weight: 212.289
• Mol file: 199177-36-1.mol

Synonyms:Acetic acid 5-hydroxy-2,6,6-trimethyl-cyclohex-1-enylmethyl ester

Chemical Property of Acetic acid 5-hydroxy-2,6,6-trimethyl-cyclohex-1-enylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid 5-hydroxy-2,6,6-trimethyl-cyclohex-1-enylmethyl ester

There total 5 articles about Acetic acid 5-hydroxy-2,6,6-trimethyl-cyclohex-1-enylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetic anhydride (108-24-7) + (+/-)-2-hydroxy-β-cyclogeraniol (199177-32-7) → Acetic acid 5-hydroxy-2,6,6-trimethyl-cyclohex-1-enylmethyl ester (199177-36-1)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/S0040-4039(97)10038-7

Reference yield:

2,6,6-Trimethyl-1,4-cyclohexadiene-1-carboxaldehyde (162376-82-1) → Acetic acid 5-hydroxy-2,6,6-trimethyl-cyclohex-1-enylmethyl ester (199177-36-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 90 percent / NaBH₄, CeCl₃*7H₂O / methanol

2: 95 percent / Et₃N / CH₂Cl₂

3: 85 percent / mCPBA / CH₂Cl₂

4: 90 percent / PTSA / methanol

5: 77 percent / LAH / tetrahydrofuran

6: 95 percent / Et₃N / CH₂Cl₂

With sodium tetrahydroborate; lithium aluminium tetrahydride; cerium(III) chloride; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0040-4039(97)10038-7

Reference yield:

(2,2,4-Trimethyl-7-oxa-bicyclo[4.1.0]hept-3-en-3-yl)-methanol (199177-31-6) → Acetic acid 5-hydroxy-2,6,6-trimethyl-cyclohex-1-enylmethyl ester (199177-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / LAH / tetrahydrofuran

2: 95 percent / Et₃N / CH₂Cl₂

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(97)10038-7

upstream raw materials:

acetic anhydride

(+/-)-2-hydroxy-β-cyclogeraniol

2,6,6-Trimethyl-1,4-cyclohexadiene-1-carboxaldehyde

(2,2,4-Trimethyl-7-oxa-bicyclo[4.1.0]hept-3-en-3-yl)-methanol

Downstream raw materials:

Acetic acid 2,6,6-trimethyl-5-oxo-cyclohex-1-enylmethyl ester