N¹-(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl)-3-methyl-butane-1,2-diamine

Base Information

• Chemical Name: N¹-(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl)-3-methyl-butane-1,2-diamine
• CAS No.: 851976-93-7
• Molecular Formula: C₂₀H₂₇FN₂S
• Molecular Weight: 346.512
• Mol file: 851976-93-7.mol

Synonyms:N¹-(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl)-3-methyl-butane-1,2-diamine

Chemical Property of N¹-(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl)-3-methyl-butane-1,2-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl)-3-methyl-butane-1,2-diamine

There total 5 articles about N¹-(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl)-3-methyl-butane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

{1-[(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl-amino)-methyl]-2-methyl-propylamino}-(9H-fluoren-9-ylmethoxy)-methanol → N1-(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl)-3-methyl-butane-1,2-diamine (851976-93-7)

Guidance literature:

With morpholine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.bmc.2005.02.011

Reference yield:

(1-{[(E)-(S)-1-Benzyl-2-fluoro-2-phenylsulfanyl-ethylimino]-methyl}-2-methyl-propyl)-carbamic acid 9H-fluoren-9-ylmethyl ester → N1-(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl)-3-methyl-butane-1,2-diamine (851976-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.42 g / NaBH₄ / methanol / 2 h / 0 °C

2: 82 percent / morpholine / dimethylformamide / 2 h / 0 - 20 °C

With morpholine; sodium tetrahydroborate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.02.011

Reference yield:

N-α-(9-fluorenylmethyloxycarbonyl)-L-valinal (156939-64-9) → N1-(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl)-3-methyl-butane-1,2-diamine (851976-93-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Na₂SO₄ / CH₂Cl₂ / 2 h / 0 - 20 °C

2: 0.42 g / NaBH₄ / methanol / 2 h / 0 °C

3: 82 percent / morpholine / dimethylformamide / 2 h / 0 - 20 °C

With morpholine; sodium tetrahydroborate; sodium sulfate; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.02.011

upstream raw materials:

N-α-(9-fluorenylmethyloxycarbonyl)-L-valinal

1-benzyl-2-fluoro-2-phenylsulfanyl-ethylamine

2-(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl)-isoindole-1,3-dione

Downstream raw materials:

1-{1-[(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl-amino)-methyl]-2-methyl-propylamino}-2-{[(9H-fluoren-9-ylmethoxy)-hydroxymethyl]-amino}-ethanol

2-amino-1-{1-[(1-benzyl-2-fluoro-2-phenylsulfanyl-ethyl-amino)-methyl]-2-methyl-propylamino}-ethanol