t-butyl [(2R)-4-[4-(4-carboxybenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate

Base Information

Chemical Name:t-butyl [(2R)-4-[4-(4-carboxybenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate
CAS No.:910550-48-0
Molecular Formula:C₂₇H₃₀F₃N₃O₆
Molecular Weight:549.547
Hs Code.:

Synonyms:t-butyl [(2R)-4-[4-(4-carboxybenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate

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Chemical Property of t-butyl [(2R)-4-[4-(4-carboxybenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate

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Technology Process of t-butyl [(2R)-4-[4-(4-carboxybenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate

There total 3 articles about t-butyl [(2R)-4-[4-(4-carboxybenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 910551-04-1
t-butyl [(2R)-4-[4-(4-methoxycarbonylbenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate

: 910550-48-0
t-butyl [(2R)-4-[4-(4-carboxybenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate

Guidance literature:: t-butyl [(2R)-4-[4-(4-methoxycarbonylbenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate; With methanol; sodium hydroxide; water; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃;

Reference yield:

: 4-(4-(tert-butoxycarbonyl)piperazine-1-carbonyl)benzoic acid

: 910550-48-0
t-butyl [(2R)-4-[4-(4-carboxybenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; diethyl ether

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether;
DOI:10.1016/j.bmcl.2012.07.019

Reference yield:

: 691394-20-4
C₁₂H₁₄N₂O₃

: 486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

: 910550-48-0
t-butyl [(2R)-4-[4-(4-carboxybenzoyl)-1-piperazinyl]-1-(2,4,5-trifluorophenyl)-4-oxobutyl]carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
DOI:10.1016/j.bmcl.2012.07.019